Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included (99m)TC- dimercaptosuccinic acid ((99m)Tc-DMSA), which is used for cortex imagi...

Leukocytes labeled with technetium-99m using pretinning with stannous complexes of pyrophosphate, glucoheptonate, and gentisic acid were compared with respect to labeling efficiency, time required for labeling, in vitro cell viability, initial lung transit, and image quality following reinjection into normal volunteers. Gentisic acid pretinning was the best method, offering the shortest prepara...

UNLABELLED Many groups have reported the adsorption or retention of (99m)Tc-radiopharmaceuticals on injection vials and disposable plastic syringes. Such an enormously high loss of radioactivity would result in poor images, radiation exposure, waste, and economic burdens. We therefore decided to investigate the extent of adsorption or retention of several (99m)Tc-radiopharmaceuticals on injecti...

Leukocytes labeled with technetium-99m using pretinning with stannous complexes of pyrophosphate, glucoheptonate, and gentisic acid were compared with respect to labeling efficiency, time required for labeling, in vitro cell viability, initial lung transit, and image quality following reinjection into normal volunteers. Gentisic acid pretinning was the best method, offering the shortest prepara...

The aim of this study was to evaluate the clinical efficacy of immunoscintigraphy with Tc-99m-labelled antigranulocyte antibody in combination with Tc-99m-methylene-diphosphonate (MDP) bone scanning in diabetic foot infection. The study group comprised 42 Type 2 diabetics with foot infection. Preand postprandial blood glucose level, HbA1c, urinary glucose, microalbuminuria, total cholesterol, L...

Amiodarone hydrochloride, which is used in life-threatening cardiac tachyarrhythmia, has been known to cause amiodarone induced pulmonary toxicity (AIPT) as a complication. In this study we aimed to investigate the clinical value of technetium-99m diethylene triamine penta-acetic acid (DTPA) aerosol lung scintigraphy in patients with AIPT in comparison with gallium-67 (Ga-67) scan. The study gr...

Samenvatting In dit prospectieve, in vivo haalbaarheidsonderzoek met 20 patiënten recidiverend prostaatkanker is onderzocht of een geminiaturiseerde DROP-IN-gammaprobe mogelijkheden biedt voor robotgeassisteerde op PSMA gebaseerde radiogeleide chirurgie (RGC) (NCT03857113). Patiënten ≤ 3 prostaatkankerrecidieven het kleine bekken (lokaal lymfeklier) PET-CT-scan na primaire behandeling werden ge...

BACKGROUND AND OBJECTIVE. There is a need for objective semiquantitative indexes for the evaluation of results of single-photon emission tomography (SPECT) in patients with brain glioma. The aim of this study was to validate the total size index (TSI) and total intensity index (TII) based on technetium-99m-methoxyisobutylisonitrile ((99m)Tc-MIBI) SPECT scans to discriminate the patients with hi...