Histamine, the best-known pruritogen in humans, is also regarded as an experimental itch-causing substance. Clinically, antihistamines, i.e., H1-receptor blockers, are used to treat all types of itch resulting from renal and liver diseases, as well as from serious skin diseases such as atopic dermatitis. Antihistamines, however, often lack efficacy in patients with chronic itch involving other ...
