An internet user wanting to share observed content is typically restricted to primitive techniques such as screenshots, web caches or share button-like solutions. These acclaimed proofs, however, are either trivial to falsify or require trust in centralized entities (e.g., search engine caches). This motivates the need for a seamless and standardized internet-wide non-repudiation mechanism, all...

An articulated leg for the use in a running robot is presented. It is driven by series elastic actuation with a highly compliant spring at the knee joint to exploit periodic energy storage and passively support a running motion. The spring is connected with the knee motor by a cable pulley system, which allows the advantageous placement of the motor in the hip joint and enables us to use a comp...

Tumor lysis syndrome (TLS) is widely recognized as a serious adverse event associated with the cytotoxic therapies primarily used in hematologic cancers, such as Burkitt lymphoma and acute lymphoblastic leukemia. In recent years, TLS has been more widely observed, due at least in part to the availability of more effective cancer treatments. Moreover, TLS is seen with greater frequency in solid ...

The TLS/FUS gene is involved in a recurrent chromosomal translocation in human myxoid liposarcomas. We previously reported that TLS is a potential splicing regulator able to modulate the 5'-splice site selection in an E1A pre-mRNA. Using an in vitro selection procedure, we investigated whether TLS exhibits a specificity with regard to RNA recognition. The RNAs selected by TLS share a common GGU...

An in vitro gas production technique was used to investigate the associative effects of untreated or biologically-treated linen straw with berseem hay (H). The linen straw (LS) was biologically treated with white rot fungi (TLS). Ground samples (200 mg DM) of H, LS, TLS and the mixtures (50% w/w) of H + LS and H + TLS were incubated in 100 ml glass syringes with buffered rumen fluid. Cumulative...

Widespread changes involving neocortical and mesial temporal lobe structures can be present in patients with temporal lobe epilepsy and hippocampal sclerosis. The incidence, pathology, and clinical significance of neocortical temporal lobe sclerosis (TLS) are not well characterized. We identified TLS in 30 of 272 surgically treated cases of hippocampal sclerosis. Temporal lobe sclerosis was def...

Tumor lysis syndrome (TLS) is a potentially life-threating complication of tumors or chemotherapy treatment. TLS commonly occurs in hematological malignancies, but it is very rare in patients with a solid tumor. In cases of solid tumors, TLS usually occurs spontaneously and after the initiation of anticancer therapy, and it has a high mortality rate. We present the novel case of a 62-year-old w...

Oxygen tension in healing tissues is heterogeneous. Increased oxygen mostly stimulates repair mechanisms and enhances tissue healing. Hyperbaric oxygen therapy increases blood and tissue oxygen content and may help maintain cellular integrity and function. Hydroxyurea (HU) is a cytotoxic agent, which leads to inactivation of ribonucleotide reductase, inhibition of cellular DNA synthesis, and ce...

DNA damage tolerance pathways allow cells to duplicate their genomes despite the presence of replication blocking lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS) and homology directed gap repair (HDGR). TLS pathways involve specialized DNA polymerases that are able to synthesize past DNA lesions with an intrinsic risk of causing point mutations. In cont...

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