BACKGROUND The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown. AIMS To determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy. METHOD Prospective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to ty...

Sex anomalies are one of the best-known cases of teratology among wild bees with different terms used to differentiate among such abnormalities. Gynandromorphs are individuals with genetically distinct male and female tissues while intersexes are genetically uniform individuals with expression of sexual features of the opposite sex. Among the three commonly accepted gynandromorph categories—bil...

Preclinical safety testing is one important step in the development of new medicines. The requirements of such testing are the subject of government regulations and may vary in details, but not in general principles, in different countries around the world. The approach to preclinical safety testing of new drugs is multidisciplinary and requires the expertise of members from many different fiel...

The study published in this issue of Birth Defects Research Part A, “Bendectin and Birth Defects: Ecological Analysis,” by Kutcher et al. (2002) deals with two aspects pertaining to the effects of Bendectin. It is an excellent research article. The first area investigated was related to the question as to whether Bendectin was a human teratogen based on ecological analysis. The second area inve...

Psaroniocompsa incrustata (Lutz) is an antropophilic species widely distributed in Central and South America. It is the vector of Onchocerca volvulus in a Brazilian focus and has been considered a plague in several areas of this country. The objective of this study was to determine the number of larval instars and to describe the morphological variations and teratologies of a population of P. i...

OBJECTIVES To determine the advantages of radiological imaging of a collection of full-term teratological fetuses in order to increase their scientific and educational value. BACKGROUND : Anatomical museums around the world exhibit full-term teratological fetuses. Unfortunately, these museums are regularly considered as "morbid cabinets". Detailed dysmorphological information concerning the ex...

OBJECTIVE The objective of this study was to report the outcomes of intrauterine pregnancies misdiagnosed as ectopic and exposed to methotrexate, a major teratogen. STUDY DESIGN We report the outcomes of all subjects who sought consultation after exposure to high-dose methotrexate to induce abortion in presumed ectopic pregnancies, which were later identified as viable intrauterine pregnancie...