stability studies play a critical role in assuring product quality at all points in the vaccine life cycle and havea major impact on the success of immunization programs worldwide. the purpose of stability study isdetermination of the vaccine quality under the variety of environmental factors and to establish a re-testperiod or a shelf life and recommended storage conditions. in this study thre...

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

Background: Thermal stability (TS) is a part of the BCG vaccine characterization by which the consistency of process in BCG vaccine production could be confirmed. To enhance the TS of the vaccine, some prevalent stabilizers in different concentrations were added to the final formulation of BCG bulk prior to Freeze-drying process. We found a formulation more effective than the current stabilizer...

Intact cholinergic innervation of visual cortex is critical for normal processing of visual information and for spatial memory acquisition and retention. However, a complete description of the mechanisms by which the cholinergic system modifies synaptic function in visual cortex is lacking. Previously it was shown that activation of the m1 subtype of muscarinic receptor induces an activity-depe...

Abstract In this study, we investigate the numerical stability of covariant BSSN (cBSSN) formulation proposed by Brown. We calculate constraint amplification factor (CAF), which is an eigenvalue coefficient matrix evolution equations constraints on cBSSN and some adjusted formulations with added to equations. The have a higher than from viewpoint CAF.

In order to improve the thermal properties of important engineering plastics, a novel kind of liquid crystalline epoxy resin (LCER), 3,3',5,5' -Tetramethylbiphenyl-4,4' -diyl bis(4-(oxiran-2-ylmethoxy)benzoate) (M1) was introduced to blend with nylon 66 (M2) at high temperature. The effects of M1 on chemical modification and crystallite morphology of M2 were investigated by rheometry, thermo gr...

We study local stability of self-gravitating fluid and stellar disk in the context of modified gravity theories which predict a Yukawa-like term in the gravitational potential of a point mass. We investigate the effect of such a Yukawa-like term on the dynamics of self-gravitating disks. More specifically, we investigate the consequences of the presence of this term for the local stability of t...

Synopsis To investigate if motor cortical representation shows plastic change after short-term somatosensory stimulation, the brain activation during the right thumb movement was compared before and after transcutaneous electric nerve stimulation (TENS) by using fMRI. The activation in the primary motor area (M1) decreased after the intervention with TENS. This reduction lasted for 30 min. The ...