BACKGROUND Tincture of opium (TOP) is currently used for maintenance therapy in treatment of opioids addiction. It contains ethanol. The present study was conducted to assess the increase in blood alcohol concentration (BAC) in its users; a process which may interfere with breath-alcohol test performed by law enforcement or traffic police. METHODS A total of 143 individuals were selected rand...

We introduce and discuss the test space problem as a part of the whole copula fitting process. In particular, we explain how an efficient copula test space can be constructed by taking into account information about the existing dependence, and we present a complete overview of bivariate test spaces for all possible situations. The practical use will be illustrated by means of a numerical appli...

Today’s simulation-centric hardware development process requires to leverage quality test suites for fault localization rather than employing them solely for detecting malfunctioning. In this article we (1) propose an extension of the model-based debugging theory to address the treatment of test suites in a well-founded way and (2) relate this novel approach to an algorithmic technique known as...