A pseudodifferential CMOS operational transconductance amplifier (OTA) with wide tuning range and large input voltage swing has been designed for very small ’s (of the order of a few nanoamperes per volt). The OTA is based on a modified four-quadrant multiplier architecture with current division. A common-mode feedback circuit (CMFB) structure has been proposed and designed using floating-gate ...

Ochratoxin A (OTA) is a mycotoxin involved in the development of chronic nephropathies and a known carcinogen. As we have shown previously, OTA activates mitogen-activated protein kinases [extracellular signal-regulated kinase 1 and 2 (ERK1/2), c-jun amino-terminal kinase (JNK), and extracellular-regulated protein kinase 38 (p38)] in proximal tubular cells (opossum kidney and normal rat kidney ...

This paper presents a 6 transistor fully differential dualended low-voltage (ULV) FGUVMOS operational transconductance amplifier (FGUVMOS-OTA), and a Gm-C filter where the FGUVMOS-OTA is used. The OTA has rail-torail operation. A basic Gm-C filter implemented with the OTA is presented. The cut-off frequency of the filter is tunable over almost 6 decades with a supply voltage below 1V.

In current scenario highresolutionADC architecture based on a resetting modulator required high gain operational Transcoductace Amplifier (OTA)and quanitizerin low-voltage nanometer-scale CMOSprocesses because of good speed and calibration-free response are becoming more popular in communication system. Proposed work achieves such high resolution, despite poor component matching using Folded ca...

Ochratoxin A (OTA) is a fungal metabolite that occurs in foods, beverages, animal tissues, human blood and presents carcinogenic, teratogenic and nephrotoxic properties. This study concerns the redox properties of OTA using electrochemical techniques which have the potential for providing insights into the biological redox reactions of this molecule. The in situ evaluation of the OTA interactio...

Ochratoxin A (OTA) is a mycotoxin with a main nephrotoxic activity contaminating several foodstuffs. In the present report, five soil samples collected from OTA-contaminated vineyards were screened to isolate microorganisms able to biodegrade OTA. When cultivated in OTA-supplemented medium, OTA was converted in OTα by 225 bacterial isolates. To reveal clonal relationships between isolates, mole...

The aim of the present study was to evaluate the effect of long-term cyanidin 3-O-β-D-glucoside (C3G) and/or Ochratoxin A (OTA)-exposure on dimethylarginine dimethylamino hydrolase/nitric oxide synthase (DDAH/NOS) pathway in rats. The experiments were performed in rats supplemented with C3G (1 g/kg feed), OTA (200 ppb), and OTA + C3G. After 4 weeks of daily treatment, liver and kidneys were pro...

AIMS To develop and validate a logistic regression model to predict the growth and ochratoxin A (OTA) production boundaries of two Aspergillus carbonarius isolates on a synthetic grape juice medium as a function of temperature and water activity (a(w)). METHODS AND RESULTS A full factorial design was followed between the factors considered. The a(w) levels assayed were 0.850, 0.880, 0.900, 0....

Background: An impediment to the rational development of novel drugs against tuberculosis (TB) is a general paucity of knowledge concerning the metabolism of Mycobacterium tuberculosis, particularly during infection. Constraint-based modeling provides a novel approach to investigating microbial metabolism but has not yet been applied to genome-scale modeling of M. tuberculosis. Results: GSMN-TB...