Abstract Background Appropriate drug distribution is needed for effective treatment of brain metastases and leptomeningeal carcinomatosis. Lack proper bioavailability in the CNS contributes to poor outcome these patients. EnClear Therapies has developed a device delivering intrathecal therapeutics utilizing active control CSF flow through an external pump. Herein, we look at delivery methotrexa...

Background: The syndrome of degenerative lumbar canal stenosis accounts for a large percentage causes low back pain in the elderly worldwide. Surgical management has demonstrated better clinical and radiological results than conservative treatment. It allows adequate decompression thecal sac compressed nerve roots. However, aggressive laminectomy with facetectomy been linked many postoperative ...

It has become apparent that in the ovary, the immune system contributes to the regulation of gonadal function. Leukocytes present within the ovary may constitute potential in-situ modulators of ovarian function that act through local secretion of regulatory soluble factors. These factors include numerous cytokines that largely originate by the action of immune cells within the ovary. Actual rup...

*Associate Professor, **Resident, Department of Medicine, ***Associate Professor, Department of Neurosurgery, ****Head of Department of Medicine, Sassoon General Hospital, Pune Received: 25.10.2012; Revised: 06.12.2012; Accepted: 27.12.2012 5 year old female , a housewife , presented with gradually progressing paraparesis since 2 yrs. There were no sensory or bowel and bladder symptoms. Tone wa...

Tubercular spinal epidural abscess (SEA) is is a devastating infectious disease. Its presence without associated osseous involvement may be considered an extremely rare scenario. We present a rare case of tubercular SEA complicated by paraplegia in an immune-competent 58-year-old male patient. MRI shows a multisegmental posterior collection of epidural fluid extending from C7 to L2 vertebral le...

The ultrastructure of huma corpora luntea obtained approximately 2, 3, 5, 11, and 15 days after ovulation is reported . All specimens were fixed in Karnovsky's formaldehyde-glutaraldehyde solution . The 5-day corpus luteum is presumed to represent, in terms of fine structure, the ultrastructural aspects of high progesterone production and is compared to younger differentiating and older regress...

Twelve horses underwent standing laparoscopic ovariectomy using electrocoagulation and fine dissection as the only means of achieving haemostasis of the severed ovarian pedicle. Four mares had bilateral ovariectomy performed as a treatment for aggressive behaviour thought to be associated with the oestrous cycle. Eight mares had unilateral ovariectomy performed for removal of a granulosa thecal...

INTRODUCTION The National Institute for Health and Care Excellence (NICE) estimates that each year in the UK around 2.5 million people will approach their GP with back pain. Fortunately most cases are due to nonspecific causes and are often self-limiting. Metastatic spinal cord compression (MSCC) is one of the ominous causes of back pain where there is a compression of the thecal sac and its co...

SUMMARY Spinal intradural extramedullary capillary hemangiomas are extremely rare. We present the MR imaging and histologic findings in three patients with this abnormality. The three patients were men who had symptoms of either myelopathy (n = 2) or radiculopathy (n = 1). The tumors were well demarcated, 1.5-2.0 cm in diameter, and were located at the posterior or posterolateral portion of the...

The authors present a rare case of lumbar vertebral hemangioma extending to the epidural space with a bisected appearance and impinging on thecal sac. This 52-year-old lady presented with one year history of low back pain and bilateral leg radiation. Plain radiography showed vertical linear streaks at L2 vertebral body and axial computed tomography (CT) scan revealed small "polka dot" appearanc...