Antibody-drug conjugates are a promising therapeutic class of cytostatic agents. They consist monoclonal antibody, usually the IgG type, to which one or more molecules cytotoxic drug conjugated via suitable linker (covalent chain). The form has significantly lower toxicity than free form, cannot be used alone in therapy. Czech State Institute for Drug Control database so far registered 9 antibo...

Antibodies can swiftly provide therapeutics to target disease-related molecules discovered in genomic research. Antibody engineering techniques have been actively developed and these technological innovations have intensified the development of therapeutic antibodies. From the mid-1990's, a series of therapeutic antibodies were launched that are now being used in clinic. The disease areas that ...