Staphylococcus pseudintermedius is a commensal organism of companion animals that is a significant source of opportunistic infections in dogs. With the emergence of clinical isolates of S. pseudintermedius (chiefly methicillin-resistant S. pseudintermedius (MRSP)) exhibiting increased resistance to nearly all antibiotic classes, new antimicrobials and therapeutic strategies are urgently needed....

Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity against C.albicans, C.glabrata, C.krusei, and C.parapsilopsis. The structures of the newly synthesized compounds 3a-3l were confirmed by IR, ¹H-NMR, 13C-NMR, and ESI-MS spec...

In the search for new fluorescent triphenylamine (TP) derivatives, we studied influence of position and substitution diverse heterocyclic substituents. A library 10 triphenylamines bearing either oxazoles or thiazoles pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C−H activation reaction between pyridine-oxazoles pyridine-thiazoles di-i...

Abstract: Aim/ Background: Pancreatic lipase (PL) inhibition has been suggested to be an effective method for obesity management. In this study, 10 novel thiazole-benzimidazole conjugates were designed. Materials and Methods: Conjugates initially screened via in silico experiments, such as ADMET analysis molecular docking, identify the most promising PL inhibitors. Results: Results revealed tha...

Thiamine pyrophosphate is required as a coenzyme for several enzymatic reactions which result in the decarboxylation of cu-keto acids with the concomitant formation of corresponding aldehydes or their condensation products (a-keto alcohols). A number of investigators (l-3) have found that thiamine will catalyze the same reactions under mildly alkaline conditions in the absence of enzymes. This ...

The rise of bacterial resistance to common clinical antibiotics is calling for alternative techniques synthesize antibacterial drugs with high biodegradability. For instance, microwave-assisted synthesis a powerful technique that accelerates organic reactions. Here, we report the 19 thiophene derivatives, five furan and two thiazole using Suzuki–Miyaura cross-coupling by microwave irradiation. ...

Thiamine (vitamin B1) is essential for brain function because of the coenzyme role thiamine diphosphate (ThDP) in glucose and energy metabolism. In order to compensate deficiency, several precursors with higher bioavailability were developed since 1950s. Among these, thioester benfotiamine (BFT) has been extensively studied beneficial effects both rodent models neurodegeneration human clinical ...