Although the structure of thiamin (vitamin B,) has been known for over 40 years (Williams, 1936; Grewe, 1936) and its chemical synthesis accomplished soon thereafter (Williams & Cline, 1936; Andersag & Westphal, 1937; Todd & Bergel, 1937), the biosynthetic pathway to thiamin (3) has still not been elucidated completely. It is well established that the pyrimidine (1) and thiazole (2) moieties ar...

The new cyclic peptide antibiotic, radamycin (1) and the known thiopeptide methylsulfomycin I (2) have been isolated from the fermentation broth of a Streptomyces sp. RSP9. The structure of radamycin was elucidated by NMR, LC-MS and FAB-MS and was established as a thiopeptide with oxazole and thiazole moieties, and several unusual amino acids.

The first intermediates in the metabolism of thiamine by a microorganism isolated from soil are Z-methyl-4-amino-5hydroxymethylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole. The pyrimidine is further metabolized, first to 2-methyl-4hydroxy-5-hydroxymethylpyrimidine followed by 2-methyl4-hydroxy-5-pyrimidine-carboxylic acid. The thiazole metabolites 4-methylthiazole-5-acetic acid and 2-oxyd...

Photochromism in a diarylethene derivative (1O) can be gated by a host-guest interaction where the thiazole orange groups are bound into the hydrophobic cavity of CB[8] in water. The closed-ring isomer (1C), which cannot be obtained freely in aqueous solution, survives even when the complex is dissociated by displacement from CB[8] by competition with 1-adamantanamine hydrochloride.

DFT quantum chemical computations have been carried out at the B3LYP/6-31G(d) level. Full geometry optimization has been performed and equilibrium geometries for a new series of phenyl thiazoles have been located. Ground state electronic properties, charge density distributions, dipole moments and its components have been calculated and reported. Effect of substituents on the geometry and on th...

Condensation of 3-acetylbenzo[5,6]coumarin (1) with hydrazine-carbodithioate esters and/or thiocarbohydrazide gave the corresponding N-[1-(benzocoumarin-3`-yl)ethylidene]hydrazonecarbodithioate (2a,b) and 1,5-bis[1-(benzocoumarin3`-yl)ethylidene]thiocarbohydrazide (3) respectively. Treatment of 2a with ethanolic ammonia solution and/or amines gave the corresponding thiosemicarbazone derivatives...

Two novel tetrathiafulvalene (TTF) containing compounds 1 and 2 have been synthesised via a four-fold Stille coupling between a tetrabromo-dithienoTTF 5 and stannylated thiophene 6 or thiazole 4. The optical and electrochemical properties of compounds 1 and 2 have been measured by UV-vis spectroscopy and cyclic voltammetry and the results compared with density functional theory (DFT) calculatio...

New anxiolytics have been discovered by prediction of biological activity with computer programs pass and derek for a heterogeneous set of 5494 highly chemically diverse heterocyclic compounds (thiazoles, pyrazoles, isatins, a-fused imidazoles and others). The majority of tested compounds exhibit the predicted anxiolytic effect. The most potent activity was found in 2-(4-nitrophenyl)-3-(4-pheny...

In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with h...

Intramolecular dipolar cycloaddition of bicyclic münchnones, 5H,7H-thiazolo[3,4-c]oxazol-4-ium-1-olates, derived from cyclodehydration of 2-substituted-N-acylthiazolidine-4-carboxylic acids are reported. A range of new pyrrolo[1,2-c]thiazole derivatives (7, 14, 15, 20, 23, and 26) were obtained as single enantiomers from 2-phenylthiazolidines, 2-benzoylthiazolidines, and 2-methylthiazolidine-4-...