Three-dimensional models of thrombin complexed with large fragments of the fibrinogen Aalpha and Bbeta chains are presented. The models are consistent with the results of recent mutagenesis studies of thrombin and with the information available on naturally occurring fibrinogen mutants. Thrombin recognizes fibrinogen with an extended binding surface, key elements of which are Tyr(76) in exosite...

complex heat transfer phenomena (including unsteady state conduction, convection and solidification processes) occur in steel belt conveyer sulfur granulating method. numerical simulation of this technique is performed via a comprehensive and multifaceted one dimensional model. since the air situated between the adjacent sulfur pastilles is essentially stagnant, therefore, the surface temperatu...