Thrombotic microangiopathy comprises a spectrum of clinical and lab findings including microangiopathic hemolytic anemia, thrombocytopenia, and thrombosis of capillary and arterioles. Platelet and hyaline thrombi with complete or partial occlusion of these vessels are integral histopathological findings. These findings are seen irrespective of cause and organ involved. Pathogenesis and prognosi...

A 6-year-old boy presented with microangiopathic hemolytic anemia, thrombo-cytopenia, altered sensorium and intractable bleeding. A diagnosis of thrombotic thrombocytopenic purpura was made and the child recovered dramatically after plasmapheresis. Recent developments in the understanding of TTP are reviewed, including the importance of a metaloprotease required to cleave multimers of von Willi...

Presentation The principle presenting signs of TP is collapse and death of young piglets. It is only seen in the progeny of sows (not gilts) although confusion can arise as a result of fostering. The signs can be seen in 2 age brackets. The first is unusual or rarely recognised and occurs at 3 days of age. More commonly, it is seen around and beyond 14 days of age (10-20 days). The whole litter...