background : coronary artery diseases are one of the causes of early death all over the world. in developed countries, ischemic heart disease is responsible for the half of the entire mortalities; however in developing countries it is estimated from 9 million deaths per year annually 32 percent of all deaths due to coronary artery disease. acute coronary syndromes are responsible for over 250,0...

A ngiography has been used to monitor the effects of thrombolytic therapy on coronary artery anatomy and flow during the early hours of acute of myocardial infarction since the early 1980s.1-3 Several early investigators noted a spectrum of responses of initially occluded coronary arteries to thrombolytic therapy using angiographic assessment.4,5 The Thrombolysis in Myocardial Infarction (TIMI)...

BACKGROUND Treatment delay in the management of ST-elevation myocardial infarction conversely correlates with prognosis and survival of the patients. This study aimed to investigate factors associated with delay in the thrombolytic therapy of these patients in Tehran. METHODS Between 2007 and 2010, the interval between the self-reported time of the onset of symptoms and initiation of the thro...

The pharmacokinetic and thrombolytic properties were determined of two recombinant single-chain chimeric plasminogen activators (PA) consisting of u-PA-33k, a low-molecular weight derivative of single-chain urokinase-type PA (scu-PA) comprising amino acids Ala132 through Leu411, and of either a single-chain variable region fragment (Fv) derived from the fibrin fragment D-dimer-specific monoclon...

Background: Thrombolytic therapy used in patients with acute myocardial infarction may increase the risk of stroke. Scant information is available from community-based studies. Summary of Report: Among 5,635 consecutive patients admitted with acute myocardial infarction to hospitals in Seattle and surrounding suburban King County, Washington, 116 (2.1%) experienced strokes during hospitalizatio...

CONTEXT A meta-analysis found that primary percutaneous transluminal coronary angioplasty (PTCA) was more effective than thrombolytic therapy in reducing mortality from acute myocardial infarction. However, fewer than 20% of U.S. hospitals have facilities to perform PTCA and many clinicians must choose between immediate thrombolytic therapy and delayed PTCA. COUNT The number of minutes of PTC...

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the ...