نتایج جستجو برای: thrombopoietin

تعداد نتایج: 1701  

Journal: :Blood 2011
Solène Evrard Olivier Bluteau Micheline Tulliez Philippe Rameau Patrick Gonin Eva Zetterberg Jan Palmblad Arnaud Bonnefoy Jean-Luc Villeval William Vainchenker Stéphane Giraudier Orianne Wagner-Ballon

Transforming growth factor-β1 (TGF-β1) is the most important cytokine involved in the promotion of myelofibrosis. Mechanisms leading to its local activation in the bone marrow environment remain unclear. As a recent study has highlighted the role of thrombospondin-1 (TSP-1) in platelet-derived TGF-β1 activation, we investigated the role of TSP-1 in the TPO(high) murine model of myelofibrosis. T...

2015
Monica Carpenedo Silvia Cantoni Veronica Coccini Marilena Fedele Enrica Morra Enrico Maria Pogliani

Thrombopoietin mimetics are new treatment options for patients with immune throm-bocytopenia (ITP). Because of their mechanism of action, long-term administration was envisioned in order to maintain effective thrombopoiesis. We report on 30 romiplostim treated patients: 13/27 responders (48%) achieved stable platelet counts on a mean romiplostim dose of 2.43 µg/kg and were able to stop romiplos...

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