Shigella flexneri, the pathogen responsible for bacillary dysentery, has evolved multiple strategies to control the inflammatory response. Here, we show that Shigella subverts the subcellular trafficking of the intercellular adhesion molecule-1 (ICAM-1), a key molecule in immune cell recruitment, in a mechanism dependent on the injected bacterial enzyme IpgD and its product, the lipid mediator ...

The interfacing of colloidal nanoparticles with mammalian cells is now well into its second decade. In this review our goal is to highlight the more generally accepted concepts that we have gleaned from nearly twenty years of research. While details of these complex interactions strongly depend, amongst others, upon the specific properties of the nanoparticles used, the cell type, and their env...

Meiotic crossover (CO) recombination facilitates evolution and accurate chromosome segregation. CO distribution is tightly regulated: homolog pairs receive at least one CO, CO spacing is nonrandom, and COs occur preferentially in short genomic intervals called hotspots. We show that CO number and distribution are controlled on a chromosome-wide basis at the level of DNA double-strand break (DSB...

The KRAS mutation remains the most common driver mutation in patients with non-small cell lung cancer (NSCLC) and confers a poor prognosis. Thus far, efforts to target this mutation over the last two decades have been unsuccessful. Over the past 5 years, many efforts to develop drugs that target the RAS-RAF-MEK-ERK (MAPK) pathway have resulted in enhanced understanding of the KRAS mutant NSCLC ...

Protein tyrosine phosphatase 1B (PTP1B) is known to promote the pathogenesis of diabetes and obesity by negatively regulating insulin and leptin pathways, but its role associated with colon carcinogenesis is still under debate. In this study, we demonstrated the oncogenic role of PTP1B in promoting colon carcinogenesis and predicting worse clinical outcomes in CRC patients. By co-immunoprecipit...

1 Background and Objectives 1.1 Terminological and conceptual preliminaries: ‘Creoles’, ‘Creole genesis’, ‘Creolization’, etc. 1.2 Uniformitarian boundary conditions 1.3 Cartesian boundary conditions 1.4 Some landmarks for navigating through the many detours of this long essay 2 Whence ‘Creole Genesis’? 2.1 Making constructive use of the distinction and relation between ‘I-languages’ and ‘E-lan...

In this report we describe a method for extracting curves from an image using directional pixel variances instead of gradient measures as low-level boundary evidence. The advantage of the variance over the image gradient is that we can accurately compute the direction of a local edge even if a sudden contrast change occurs in the background. This allows curves belonging to object contours to be...

slayer of Argus, did as he was told. Forthwith he bound on his glittering golden sandals with which he could fly like the wind over land and sea … he swooped down through the firmament till he reached the level of the sea, whose waves he skimmed like a cormorant that flies fishing every hole and corner of the ocean, and drenching its thick plumage in the spray. T echnologies developed during th...