Dustin and Auerbach7 considered that lymphocytes initially arose from the el)ithelium of the thymus anlage, while Maximow thought they were derived from associated mesenchymal cells.8 In the adult thymus, the lymphocytes would come chiefly from divisions of preexisting lymphocytes and occasionallv from reticular ceIls2,6,M ( which may he either epithelial or mesenchyrnalt’). In the course of ou...

The thymus is a vertebrate-specific organ where T lymphocytes are generated. Genetic programs that lead to thymus development are incompletely understood. We previously screened ethylnitrosourea-induced medaka mutants for recessive defects in thymus development. Here we report that one of those mutants is caused by a missense mutation in a gene encoding the previously uncharacterized protein WD...

Previous studies revealed that thymus is a targeted immune organ in malnutrition, and high-boron stress is harmful for immune organs. African ostrich is the living fossil of ancient birds and the food animals in modern life. There is no report about the effect of boron intake on thymus of ostrich. The purpose of present study was to evaluate the effect of excessive boron stress on ostrich thymu...

RATIONALE Chorioamnionitis is associated with preterm delivery and involution of the fetal thymus. Women at risk of preterm delivery receive antenatal corticosteroids which accelerate fetal lung maturation and improve neonatal outcome. However, the effects of antenatal corticosteroids on the fetal thymus in the settings of chorioamnionitis are largely unknown. We hypothesized that intra-amnioti...

The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration ...

The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is...

Transplantation of thymus and bone marrow cells from irradiated C57BL/Ka mice demonstrated the presence of potentially neoplastic cells in the thymus at 30 to 60 days postirradiation. During the same interval, no such cells could be detected in the bone marrow; moreover, the capacity of bone marrow cells to repopulate the thymus was impaired severely. These observations suggest that the primary...

ture of both thymus and thyroid. The discovery of the thyro-thymic lymphatic channels is not of recent date, but was the result of work done by Sir Astlv Cooper, who described them in 1832. Recently, Sir Arthur Keith has found in the museum of the Royal College of Surgeons, England, injection specimens of thyroid and thymus attributed to Sir Astly Cooper. In a ' Physiological essay 011 the thym...

Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymoc...