The ability of asialo-thyroglobulin to bind the thyroid RHL-1 subunit of the asialoglycoprotein receptor has been investigated. Ligand blot assays show that the recombinant carbohydrate recognition domain of the thyroid RHL-1 subunit specifically interacts with rat desialated thyroglobulin. Moreover, RT-PCR and Western blot assays show that TSH deprivation decreases RHL-1 expression in PC C13 t...

Mục tiêu: Nồng độ Thyroglobulin huyết thanh được sử dụng để theo dõi sự tái phát hoặc tiến triển của ung thư tuyến giáp biệt hóa. Vai trò việc định lượng thyroglobulin trước phẫu thuật còn chưa rõ ràng. Chúng tôi thực hiện nghiên cứu này nhằm góp phần đánh giá nồng và mối liên quan với một số yếu tố ở người bệnh thể Phương pháp: Nghiên cứu, mô tả cắt ngang; Dữ liệu thu thập bao gồm nhân khẩu họ...

Thyroglobulin autoantibodies (TgAb) are detected at diagnosis or during treatment in approximately 25% of patients with differentiated thyroid cancer (DTC). When present, TgAb interferes with thyroglobulin (Tg) measurement causing falsely low or undetectable Tg immunometric assay (IMA) values that can mask disease. Guidelines mandate that every Tg test have TgAb measured simultaneously and quan...

Sera from certain patients with Hashimoto's disease or a related condition contain a non-precipitating antithyroglobulin which produces in double-diffusion tests with thyroglobulin a line of clearing in the agar. Two such sera are described. Other sera from examples of the disease give negative precipitin tests with thyroglobulin but combine with sera containing ;clear line', non-precipitating ...

A mast cell protease has been purified over 260-fold from rat thyroid homogenates. The purified enzyme hydrolyzes denatured thyroglobulin, denatured hemoglobin, and fibrinogen. It also rapidly hydrolyzes the ester substrates, benzoyltyrosine ethyl ester, benzoylphenylalanine ethyl ester, and acetyltyrosine ethyl ester. The pH optimum for thyroglobulin and benzoyltyrosine ethyl ester hydrolysis ...

A simple and reproducible hemagglutination technique for detecting microsomal and thyroglobulin antibodies has been evaluated in normal subjects and in patients with thyroid disease. Microsomal antibodies were detected in 89 percent of all patients with autoimmune thyroid disease and in 97 percent of patients with biopsy proven Hashimoto's thyroiditis. In contrast, thyroglobulin antibodies were...