BACKGROUND Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5-8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid gland are extremely rare and reported scarce...

Hyperfunctioning nodules of the thyroid are thought to only rarely harbor thyroid cancer, and thus are infrequently biopsied. Here, we present the case of a patient with a hyperfunctioning thyroid nodule harboring thyroid carcinoma and, using MEDLINE literature searches, set out to determine the prevalence of and characteristics of malignant "hot" nodules as a group. Historical, biochemical and...

E-Cadherin (CDH1) expression is reduced in thyroid carcinomas by primarily unknown mechanisms. In several tissues, SNAIL (SNAI1) and SLUG (SNAI2) induce epithelial-mesenchymal transition by altering target gene transcription, including CDH1 repression, but these transcription factors have not been studied in thyroid carcinoma. Recently, our group has provided direct evidence that ectopic SNAI1 ...

INTRODUCTION The aim of this study was to investigate the roles of nutritional habits and addictions in the incidence of thyroid carcinoma. MATERIAL AND METHODS The study of risk factors affecting the incidence of thyroid carcinoma was conducted in patients included in a register of thyroid carcinoma. For that purpose, a questionnaire was prepared. The questionnaire covered: personal informat...

This was an extremely rare case of unusual granular cell tumor of the trachea coexisting with recurrent papillary thyroid carcinoma. We initially misdiagnosed this patient as having tracheal invasion from recurrent thyroid carcinoma even after a computed tomography scan and fine-needle aspiration cytology.Clinicians should be aware of the possibility of granular cell tumor of the trachea occurr...

Protein tyrosine kinases (PTKs) play a role in regulating the growth and differentiated functions of thyroid cells and are probably involved in tumorigenesis of papillary-type thyroid carcinoma. To better understand the roles of PTKs in the physiology and pathophysiology of the thyroid, we analyzed the expression profile of receptor-type PTKs in normal human thyroid tissues. Highly conserved re...

Follicular thyroid carcinoma classically accounts for 10-32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed. The medical records of all patients who underwent thyroidectomy from October 1998 to April 2...

BACKGROUND Thyroid nodules with cystic content or mixed sponge-like aspect on ultrasonography and a concordant cytology are strongly predictive of benignity. OBJECTIVES We present 8 patients with honeycomb-like papillary thyroid carcinoma with multiple small cysts on ultrasonography. METHODS The patients were 6 women and 2 men aged between 30 and 57 years. The tumors of these patients showe...

AIMS AND BACKGROUND Lymph node metastases are rare in patients with follicular thyroid carcinoma, with an average incidence of 5.5% of all cases reported in the literature. In the present study we focused on the search for risk factors predictive of lymph node involvement in patients with follicular thyroid carcinoma to plan the most appropriate management and follow-up. METHODS AND STUDY DES...

Thyroglossal duct cysts are the most frequently encountered congenital neck masses having a malignancy rate of 1%. The most common malignant form is papillary thyroid carcinoma. Synchronous papillary thyroid carcinoma developing in the thyroglossal duct cyst is rarely seen. Synchronized papillary carcinoma can be described as a multifocal tumor or a metastatic lesion on a thyroglossal duct cyst...