The purpose of this study was to establish normal thyroglobulin (Tg) reference intervals (RIs) in regions with adequate and more than adequate iodine intake according to the National Academy of Clinical Biochemistry (NACB) guidelines and to investigate the relationships between Tg and other factors.A total of 1317 thyroid disease-free adult subjects (578 men, 739 nonpregnant women) from 2 citie...

Aim. Serological indicators of organ function can reveal intrinsic links between different organs. The present study aimed to determine the correlations of serum indicators for gastric and extragastric function. Methods. A total of 823 individuals were enrolled. Data on indicators reflecting blood lipids, blood glucose, indexes of stomach, kidney, liver, and thyroid function, and H. pylori IgG ...

Background: The clinical association between rheumatoid arthritis (RA) and hypothyroidism is important as both these conditions are associated with metabolic syndrome (MetS) which in turn makes the patients more prone for cardiovascular disease. Material and methods: In this cross-sectional study, the prevalence of thyroid disorders and MetS were studied in 54 consecutive adult patients with RA...

OBJECTIVES The diagnosis and treatment of thyroid diseases in pregnant women remains a challenge. Various medical associations recommend establishing the reference intervals for thyroid hormones by a local laboratory. Considering differences within geophysical, socioeconomic conditions, and iodine prophylaxis in various populations, it is advisable to assess reference intervals for thyroid horm...

BACKGROUND/AIM Increasing evidence is available about the role of prolactin in the development of various cancers. The purpose of this study is to evaluate the frequency of thyroid cancer in patients with prolactinoma followed at a single site. MATERIALS AND METHODS The medical records of 182 patients diagnosed with prolactinoma were reviewed retrospectively. Serum prolactin, antithyroglobuli...

Objectives: To find an association between circulating oestradiol and thyroid autoimmunity in females with polycystic ovarian syndrome (PCOS) its impact on their health. Materials Methods: This study was conducted at Aziz Fatimah Medical Dental College, after obtaining ethical approval from Institutional Ethical Committee (letter No. DME/568-19) April to September 2017. Hundred PCOS enrolled th...

Subclinical hypothyroidism (SCH) is a common clinical condition, whereas it's natural course has not been identified distinctly. We evaluated the natural history of 169 SCH patients over 5-yr and the prognostic factors including thyroid autoantibodies and thyroid ultrasonographic (USG) findings related to develop overt hypothyroidism. After 5 yr, 47.3% of patients showed normalization of TSH, w...

Objectives: Within the last two decades, an increase has been seen both in autoimmune diseases and obesity, therefore, correlation between obesity autoimmunity questioned many studies have conducted on this issue. Based relationship, we aimed to determine whether weight loss affects thyroid peroxidase (TPO) antibody levels of obese individuals with or not. Methods: The patients who were aged ov...

Glutathione (GSH) was oxidized to GSSG in the presence of H2O2, tyrosine, and peroxidase. During the GSH oxidation catalyzed by lactoperoxidase, O2 was consumed and the formation of glutathione free radical was confirmed by ESR of its 5,5'-dimethyl-1-pyrroline-N-oxide adduct. When lactoperoxidase was replaced by thyroid peroxidase in the reaction system, the consumption of O2 and the formation ...

Familial Mediterranean Fever (FMF) is an auto inflammatory disease[1] and also it can occur together with autoimmune disorders, such as Behçet's syndrome and systemic Lupus erythematosus[2,3]. Here, we present Familial Mediterranean fever and Hashimoto’s thyroiditis association in a 10-year-old girl. This girl was admitted to our hospital with a history of intermittent abdominal pain, fever, he...