UNLABELLED Elevated thyroid-stimulating hormone (TSH) was discovered by routine neonatal screening in a newborn with no clinical symptoms. Thyroid function tests were repeated and confirmed a high TSH value but normal total thyroxine (T4) and triiodothyronine (T3). However, the mother also had elevated serum TSH with normal levels of T4 and T3. The results suggested a transmitted maternal inter...

Thyroid stimulating hormone-secreting pituitary adenomas (TSHomas) are uncommon tumors of the anterior pituitary gland. Patients with TSHomas may present with hyperthyroidism, but the incidence of thyroid storm due to TSHomas has yet to be determined. We report a rare case of thyroid storm caused by TSHoma in a 54-year-old woman. Preoperatively she had symptoms of excessive sweating and palpita...

Central congenital hypothyroidism (CCH) is more prevalent in children born to women with hyperthyroidism during pregnancy, suggesting a role for thyroid hormone (TH) in the development of central thyroid regulation. Using the zebrafish embryo as a model for thyroid axis development, we have characterized the ontogeny of negative feedback regulation of thyrotrope function and examined the effect...

Autoimmune thyroid diseases (AITD) are characterized by the presence of thyroid-specifi c autoantibodies. These are direc ted against thyroid microsomes, for which the main target antigen is thyroid peroxidase (TPO), against thyroglobulin (TG), or against the thyroid stimulating hormone (TSH) receptor. AITD frequently occur in combination with other autoimmune diseases, such as myasthenia gravi...

Primary hypothyroidism is a graded phenomenon with a wide spectrum of severity between subclinical hypothyroidism and overt hypothyroidism. Patients with biochemically severe hypothyroidism may present with only mild clinical manifestations, whereas some patients with moderate changes in thyroid hormones may present with severe signs of tissue hypothyroidism. The measurement of pituitary thyroi...

ABSTRACT: Hypothyroidism is rarely observed in cats. This article reports the case of a thirteen-year-old feline with one-year history bilateral cervical swelling that had majorly grown size two weeks prior to animal’s admission. The cat presented dysphonia, lethargy, weight gain, and constipation. On physical examination, hypothermia was observed, rectal temperature 36.5 ºC. Fine-needle aspira...

Differentiated thyroid cancer is the most common endocrine malignancy and the incidence is increasing rapidly worldwide. Appropriate diagnosis and post-treatment monitoring of patients with thyroid tumours are critical. Fine needle aspiration cytology remains the gold standard for diagnosing thyroid cancer, and although there have been significant refinements to this technique, diagnostic surge...

BACKGROUND Thyroidectomized patients need variable doses of levothyroxine (LT4) to obtain target thyroid-stimulating hormone (TSH) levels. Individual feedback set-points have been hypothesized and the influence of several genes in the regulation of the pituitary-thyroid axis has been demonstrated. OBJECTIVES We hypothesized that genetic variants of the TRHR gene could be associated with a dif...

UNLABELLED BACKGROUND Both thyroid stimulating hormone (TSH) and thyroid stimulating antibody (TSAb) negative Graves's disease (GD) is extremely rare. Here we present such a patient. CASE PRESENTATION The patient was a 76-year-old woman who was diagnosed as having schizophrenia forty years ago. She did not show characteristic symptoms for hyperthyroidism, such as swelling of thyroid, exoph...