curves for proportion of patients who developed overt thyrotoxicosis according to aetiology showed no significant differences (P = 0Æ557; log-rank test). Results obtained in our patients are similar to those reported by Rosario, who found that progression to overt hyperthyroidism occurred in 20% of 30 women with Graves’ disease and in 40% of 15 women with nodular disease. On the contrary, Woebe...

OBJECTIVE Amiodarone-induced thyrotoxicosis (AIT) is a challenging management problem, since patients treated with amiodarone invariably have underlying heart disease. Consequently, thyrotoxicosis can significantly contribute to increased morbidity and mortality. The aim of this study was to compare the clinical outcome and hormone profiles of patients with AIT (n = 60) with those with Graves' ...

INTRODUCTION Thyroid hormone has profound effects on a number of metabolic processes in virtually all tissues but the cardiovascular manifestations are prominent usually creating a hyperdynamic circulatory state. Thyrotoxicosis is not a common cause of congestive heart failure among black communities. OBJECTIVES To determine the hospital prevalence, clinical characteristics and echocardiograp...

Based largely on evidence of increased target tissue beta-adrenergic receptor densities and responsiveness in animal and, to a lesser extent, human tissues, it is often assumed that thyroid hormone excess results in increased sensitivity to catecholamines in vivo, thus explaining several clinical manifestations of thyrotoxicosis. To test the hypothesis that thyrotoxicosis results in increased t...

Amiodarone is used increasingly in a number of cardiac conditions. Amiodarone is heavily iodinated and can cause thyroid dysfunction. The diagnosis of amiodarone-induced thyrotoxicosis remains difficult and more common causes of thyrotoxicosis need to be considered and excluded. Amiodarone has a significant side effect profile, which includes thyroid dysfunction. Amiodarone is an effective drug...

Functional thyroid carcinoma is an unusual cause of thyrotoxicosis. We describe the clinical presentation and treatment of a patient with thyrotoxicosis due to functional thyroid carcinoma and Graves disease, and discuss potential mechanisms causing the thyrotoxicosis. A 79-year-old woman with a remote history of hemithyroidectomy and current hyperthyroidism came to the hospital with upper and ...

For many years the hemodynamics of thyrotoxicosis have been of interest to clinicians. Blood flow through the extremities was assumed to be increased in thyrotoxicosis because of the high rate of heat elimination when the hand was placed in a calorimeter (1). Several workers found an increase in cardiac output in thyrotoxic subjects using the oxygen content of arm vein blood in the Fick formula...

Received 8/6/2007; revised 9/3/2007; accepted 9/4/2007. For correspondence or reprints contact: Bi-Fang Lee, M.D., Ph.D., Department of Nuclear Medicine, National Cheng Kung University Hospital. 138 Sheng-Li Road, Tainan 704, Taiwan. Tel: (886)6-2353535 ext. 2483, Fax: (886)6-2766609, E-mail: [email protected] We performed an I thyroid imaging on a 26-year-old man who had the clinical feat...

The effect of thyrotoxicosis on the electrocardiogram of the patient, in whom there is no clinical evidence of other types of heart disease and no cardiac arrhythmia, has been a subject of considerable controversy. Joll (1932) maintained that electrocardiographic changes are produced that are pathognomonic of thyrotoxicosis, while other authorities have denied this and have stated that no speci...

The thyroid function and antithyroidal antibody were studied in 17 patients with silent thyroiditis unrelated to pregnancy. The antimicrosomal hemagglutination antibody (MCHA) was negative in ten of them (group I) and was positive in seven (group II). At one month after the thyrotoxicosis, thyroid function became normal in both groups. At two months after the onset of thyrotoxicosis, in group I...