Flavivirus infections are the most prevalent arthropod-borne infections world wide, often causing severe disease especially among children, the elderly, and the immunocompromised. In the absence of effective antiviral treatment, prevention through vaccination would greatly reduce morbidity and mortality associated with flavivirus infections. Despite the success of the empirically developed vacc...

The interferon-induced mouse Mx1 protein has intrinsic antiviral activity against orthomyxoviruses, including Thogoto virus. Thus, Mx1(+) A2G mice are apparently resistant to infection following needle- or tick-borne virus challenge. However, tick-borne challenge and, to a lesser degree, injection of virus mixed with tick salivary gland extract resulted in virus transmission to uninfected ticks...

BACKGROUND Tick-borne relapsing fever spirochetes are maintained in endemic foci that involve a diversity of small mammals and argasid ticks in the genus Ornithodoros. Most epidemiological studies of tick-borne relapsing fever in West Africa caused by Borrelia crocidurae have been conducted in Senegal. The risk for humans to acquire relapsing fever in Mali is uncertain, as only a few human case...

Journal of E Abstract There is increasing concern regarding wildlife zoonoses. It is important that veterinarians are able to give their clients and the general public appropriate advice regarding the potential risks, what to do in the event of possible exposure, input regarding early recognition of the signs of wildlife zoonotic infections, and practical advice to prevent or reduce exposure to...

Ixodes scapularis ticks transmit many infectious agents that cause disease, including tick-borne flaviviruses (TBFVs). TBFV infections cause thousands of human encephalitis cases worldwide annually. In the United States, human TBFV infections with Powassan virus (POWV) are increasing and have a fatality rate of 10 to 30%. Additionally, Langat virus (LGTV) is a TBFV of low neurovirulence and is ...

The family Flaviviridae includes human and animal pathogenic viruses of global importance, e.g. the human flaviviruses West-Nile virus (WNV), dengue virus (DENV), Japanese encephalitis virus (JEV), tick-borne encephalitis virus (TBEV) and yellow fever virus (JEV) as well as hepacivirus hepatitis C virus (HCV). This virus family was named after the jaundice occurring in course of YFV infection, ...

Ticks are obligate haematophagous arthropods present all over the world able to produce human diseases. Several factors have increased the abundance, circulation and distribution of the pathogens transmitted by ticks, contributing to the change in the vector-borne diseases epidemiology in the last years. This review collects the most important measures for the prevention and prophylaxis of tick...

Powassan virus (POWV) is an emerging tick-borne arbovirus presenting a public health threat in North America. POWV lineage II, also known as deer tick virus, is the strain of the virus most frequently found in Ixodes scapularis ticks and is implicated in most cases of POWV encephalitis in the United States. Currently, no commercial tests are available to detect POWV exposure in tick-borne disea...