Objective: Baclofen (β-p-chlorophenyl-GABA) selectively activates the GABAB subtype of γ-aminobutyric acid (GABA) receptors, a group of receptors known to provide inhibitory neurotransmission in the central nervous system. Available for over thirty years in oral form for the treatment of skeletal muscle spasticity, its availability now includes continuous intrathecal infusion via an internally ...

A variety of medications and treatment interventions, including antiepileptic drugs, tricyclic antidepressants, selective serotonin reuptake inhibitors, combined serotonin and norepinephrine reuptake inhibitors, β blockers, calcium channel antagonists, α2-adrenergic agonists, nonsteroidal anti-inflammatory drugs, muscle relaxants, occipital nerve blocks, and botulinum toxin type A injections, h...

Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. They should not exceed 750 words (including references) and may be subject to editing or abridgment. Please submit letters in duplicate, typed double-spaced. Include a fax number for the corresponding author and a completed copyright transfer agreement form (available online at To the Editor: The Editori...

BACKGROUND Breast-feeding has important health and emotional benefits for both mother and infant, and should be encouraged. While there are some data to suggest migraine may improve during breast-feeding, more than half of women experience migraine recurrence with 1 month of delivery. Thus, a thorough knowledge base of the safety and recommended use of common acute and preventive migraine drugs...

Abstract Introduction Propriospinal myoclonus (PSM) at sleep onset is characterized by jerks of axial muscles, spreading caudally and rostrally, during the transition from wakefulness to sleep1. We present a rare case patient who suffered severe sleep-onset insomnia due PSM after metoclopramide use pregnancy. Report case(s) A 30-year-old woman with history well-controlled herpes simplex virus (...

Objectives—To compare clinical eVectiveness and health related quality of life in patients with severe spasticity who received intrathecal baclofen or a placebo. Methods—In a double blind, randomised, multicentre trial 22 patients were followed up during 13 weeks and subsequently included in a 52 week observational longitudinal study. Patients were those with chronic, disabling spasticity who d...

Descrição do método de coleta de evidência Este estudo revisou artigos nas bases de dados do MEDLINE (PubMed) e demais fontes de pesquisa sem limite de tempo. Para tanto, adotou-se a estratégia de busca baseada em perguntas estruturadas na forma (P.I.C.O.) das seguintes iniciais: “Paciente”; “Intervenção”; “Controle”; “Outcome”. Como descritores, utilizaram-se: Pergunta 1: low back pain AND (an...

Topiramate appears to be useful in the prophy-laxis of several types of headache as these case histories illustrate. Patient 1.— A 42-year-old woman presented with recurring headaches since aged 8. She has severe headaches about two times per month described as a generalized throbbing with nausea and occasional vomiting lasting up to 3 or 4 days, but she does not experience aura, or light or no...