PURPOSE To analyse the available data on the effectiveness and safety of ritodrine hydrochloride in delaying delivery and in decreasing the incidence of preterm birth. METHODS Systematic review of randomised controlled trials (RCTs) that compared the effectiveness and safety of ritodrine hydrochloride with a placebo or with no treatment. Main outcome measures were relative risks (RRs) for per...

Preterm birth is the leading cause of perinatal morbidity and mortality. Fetal fibronectin (fFN), a glycoprotein in the extracellular matrix of the amniotic membranes, is the most powerful biomarker for predicting the risk of preterm birth. Biosensors using the surface plasmon resonance (SPR) response are potentially useful in quantitatively measuring molecules. We established a standard calibr...

Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although r...

The present study was undertaken to investigate the in vitro influence of mibefradil, a calcium channel blocker, and pinacidil, a potassium channel opener, on pregnant goat myometrial spontaneous rhythmic contractility and contractions induced with the agonist, oxytocin. Longitudinal strips from the distal region of uterus, collected from goats at midgestation, were mounted in an organ bath for...

We report a case of acute respiratory insufficiency due to peripartum cardiomyopathy after Caesarean section in a term pregnancy with twins. The patient was a 30-year-old woman with a spontaneous twin pregnancy at 32 weeks of gestation who was admitted to our obstetrics department with preterm premature rupture of membranes. After 48 hours, the tocolysis was stopped and an uneventful Caesarean ...

Isoxsuprine (ISOX) is a potent effective in suppressing premature with ISOX we identified seven (0.6% either prepartum in five or immedia uterine muscle relaxant and often abor. Of 1276 cases requiring tocolysis who developed acute pulmonary edema (PE) ely following delivery in two. None had co-existent heart disease. ISOX was given as an IV infusion (avg. 0.41 mg/min) for 1.5 to 9.4 days with ...

Aim: Hypoxic fetal compromises are cured by the early delivery with C-section at present, while the surgery causes maternal morbidity by uterine scar. The vaginal delivery of normal fetus after treatment in utero will cure the fetus reducing placenta accreta in succeeding delivery. Methods: 1. Maternal O2 inhalation increased fetal PaO2 in fetal distress, though the effect was insufficient. 2. ...

Background: Threatened preterm labor (TPL) is the leading cause of hospitalization during pregnancy. Tocolytic agents are the primary therapeutic options for TPL. The aim of this study is to compare intramuscular progesterone with oral nifedipine as a tocolytic agent. Methods: This randomized controlled trial was carried out in a teaching hospital (Shahid Akbarabadi) in Tehran, Iran, from Decem...

Tocolysis means drug-induced Inhibition of premature or excessive uterine activity [38], Other terms, such äs "sedation of the irritated myometrium" or "relaxation of the uterus" have the same meaning; they are, however, not commonly applied [10, 11, 17, 29]. At the beginning of the research for new substances with inhibitory effect on the uterus it was postulated that progesterone or newlydeve...

This paper intends to demonstrate that the conservative management of triplet pregnancy after delivery of one foetus is a feasible and reasonable approach. Three cases of triplet pregnancy with successful conservative management after miscarriage of one foetus, are presented and compared with cases in the literature. The route of delivery, as well as the role of tocolysis, cerclage, prophylacti...