Microcin H47 is a gene-encoded peptide antibiotic produced by a natural Escherichia coli strain isolated in Uruguay. In order to identify cellular components necessary for its antibiotic action, microcin H47-resistant mutants isolated in this work, as well as previously described mutants affected in membrane proteins, were analyzed. These studies indicated that (i) receptor outer membrane prote...

Cephalosporins have been widely used for treating diseases caused by pathogenic bacteria in human and animals. Through the tonB dependent iron transport mechanism,1>2) the use of catechol substituted /Mactams was knownto increase the drug's penetration into the bacterial cell walls. Thus, several catechol-substituted /Mactams have been synthesized and showed good antipseudomonal activities.3 ~ ...