Aim: To ascertain the prognostic value of cervical nodal necrosis (CNN) observed in patients tongue squamous cell carcinoma with magnetic resonance imaging. Materials and methods: In this retrospective observational study, records 144 diagnosed newly SCC were considered. Preoperative MRI demographic clinical data reviewed. Based on reports, categorised into: or without presence node (CNN non CN...

BACKGROUND Pulmonary metastasectomies are performed for a variety of cancers, though few reports have examined their merit for head and neck cancers. This study examined the relationship between clinical and pathological characteristics and survival after resection of lung metastases of these cancers. METHODS Between 1986 and 2013, 34 patients presenting with pulmonary metastases of primary h...

The cadherin switch from E-cadherin to N-cadherin is considered as a hallmark of the epithelial-mesenchymal transition and progression of carcinomas. Although it enhances aggressive behaviors of adenocarcinoma cells, the significance and role of cadherin switch in squamous cell carcinomas (SCCs) are largely controversial. In the present study, we immunohistochemically examined expression of E-c...

OBJECTIVES/HYPOTHESIS MK-2206 is an orally active, allosteric inhibitor of AKT, a component of the phosphatidylinositol-3 kinase (PI3K) pathway. The PI3K-AKT pathway is a downstream signaling pathway that has recently been found to play an important role in head and neck squamous cell carcinoma (HNSCC). The objective of this study is to examine the role AKT inhibition may play in treatment of H...

Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity and constitutes 95% of all cancers of this area. Men are affected twice as commonly as women, primarily if they are over 50 years of age. Forty percent of the lesions are localized in the tongue and 30% in the floor of the oral cavity. OSCC often affects upper and lower gingiva, buccal mucous membrane, the retromol...

OBJECTIVE/HYPOTHESIS The aim of this population-based study is to analyze the survival benefits of elective neck dissection (END) over neck observation in T1/T2N0M0 oral tongue squamous cell carcinoma (OT-SCC) cases. STUDY DESIGN Retrospective administrative database analysis. SUBJECTS AND METHODS The SEER database (Surveillance, Epidemiology, and End Results) was queried for patients diagn...

PURPOSE To test whether altered radiation fractionation schemes (hyperfractionation [HFX], accelerated fractionation, continuous [AFX-C], and accelerated fractionation with split [AFX-S]) improved local-regional control (LRC) rates for patients with squamous cell cancers (SCC) of the head and neck when compared with standard fractionation (SFX) of 70 Gy. METHODS AND MATERIALS Patients with st...

BACKGROUND Squamous cell cancer (SCC) of the head and neck, like other malignancies, should be reported with regard to TNM classification and treated accordingly. Sole anatomic imaging has its drawbacks, as early lesion detection often remains challenging, non-neoplastic processes can mimic malignancies and there are doubts concerning the extent of tumour. The purpose of this study was to perfo...

Background: The incidence of oral squamous cell carcinoma remains high in Indo-Pak region. Worldwide oral and oropharyngeal carcinomas are the sixth most common cancers. A number of clinic-pathological parameters have been implicated in prognosis, recurrence and survival for this tumor. As a very high frequency reported in major hospitals of Karachi, this study documented some of the well known...

Allogenic bone marrow transplantation (BMT) is a curative therapy for malignant and nonmalignant lymphohematopoietic diseases and other disorders. However, the development of secondary malignancies is an important complication among transplantation survivors. Patients who have undergone BMT have a 2to 8-fold higher risk of developing these cancers than the general population. After BMT, the mos...