Introduction Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 (T1D) and 2 diabetes (T2D). No cure for DPN available, but several potential targets have been proposed treatment. Heat shock proteins (HSPs) are known to respond hyper- hypoglycemia. can be diagnosed using electrophysiology studied nerve biopsies. Aim This study aimed analyze the presence patterns HSPs in...

Placing the tunnels in the anatomic positions is important for successful restoration of knee function after anterior cruciate ligament reconstruction (ACLR). It has been shown that it is difficult to place the tunnels in the anatomic position using the transtibial technique. The purpose of this study was to evaluate the effect of each step of our modified transtibial technique (mTT) on the pos...

Pin structures on vector bundles are the natural generalization of Spin structures to the case of nonoriented bundles. Spin(n) is the central Z/2Z extension (or double cover) of SO(n) and Pin−(n) and Pin(n) are two different central extensions of O(n), although they are topologically the same. The obstruction to putting a Spin structure on a bundle ξ (= R → E → B) is w2(ξ) H(B;Z/2Z); for Pin it...

INTRODUCTION Presence of vermiform appendix (non-inflamed or inflamed) in inguinal hernia is called Amyand's hernia in honor to surgeon C. Amyand who published the first case of perforated appendicitis within inguinal hernia in a boy caused by ingested pin. This presentation of foreign body Amyand's hernia appendicitis is very rare, and here we present such a case. CASE PRESENTATION A 6-year-...

Having multiple external fixation pin designs and insertion techniques has led to debate as to which combination creates the stiffest construct. This study sought to biomechanically evaluate construct strength using self-drilling (SD) and self-tapping (ST) pins inserted with either bicortical or unicortical fixation. SD and ST 5.0 mm stainless steel pins were used in combination with bicortical...

PURPOSE The purpose of this study was to evaluate the accuracy of a 3.5-mm-diameter anterior cruciate ligament (ACL) tibial retrograde socket drilling pin versus a standard, 2.4-mm drill-tipped guide pin. A secondary purpose was to evaluate surgeon precision in identifying the true (anatomic) center of the ACL tibial footprint using arthroscopic visualization. METHODS Six matched pairs of cad...

To gain a deeper insight into cellular processes such as transcription and translation, one needs to uncover the mechanisms controlling the configurational changes of nucleic acids. As a step toward this aim, we present here a mesoscopic-level computational model that provides a new window into nucleic acid dynamics. We model a single-stranded nucleic as a polymer chain whose monomers are the n...

BACKGROUND The first stage in the implant of a total knee arthroplasty with computer-assisted surgery is to fasten the emitters to the femur and the tibia. These trackers must be hard-fixed to the bone. The objectives of our study are to evaluate the technical problems and complications of these tracker-pins, the necessary time to fix them to the bone and the possible advantages of a new femora...

A simple, but not widely known, mathematical fact concerning the coverings of the full Lorentz group sheds light on parity and time reversal transformations of fermions. Whereas there is, up to an isomorphism, only one Spin group which double covers the orientation preserving Lorentz group, there are two essentially different groups, called Pin groups, which cover the full Lorentz group. Pin(1,...