A bioassay that used postexposure feeding depression in Daphnia magna Straus as an endpoint previously had been developed under laboratory conditions. Laboratory studies revealed that this was a sensitive, robust endpoint, which could potentially be used in an in situ bioassay. This study adapted the laboratory bioassay for use in the field and deployed D. magna in situ at four known or suspect...

Recently, Aronson and colleagues (1) reported that men withprostate cancer receiving approximately 5 g/d of fishoil combined with a low-fat diet (15% kcal from fat) for 4 to 6 weeks before prostatectomy had 32% lower tumor ki67 staining compared with men consuming a Western diet (45%kcal from fat). This study is of interest because thedata suggest that dietary modification can greatly reduce tu...

A modified bioassay system was designed to demonstrate the diffusible nature of endothelium-derived contracting factor(s) released by acetylcholine in the aorta of spontaneously hypertensive rat. In "sandwich"-like layered preparation, isometric tension was recorded from a bioassay strip (without endothelium) in the presence of N(G)-nitro-L-arginine and tetrahydrobiopterin to selectively potent...

PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activity data of small molecules and RNAi reagents. The mission of PubChem is to deliver free and easy access to all deposited data, and to provide intuitive data analysis tools. The PubChem BioAssay database currently contains 500,000 descriptions of assay protocols, covering 5000 protein targets, 30,000 gene targe...

the european corn borer (ecb) is one of the most important insect pests of corn and some other crops such as rice in iran. this pest is one of the most important hosts of the entomopathogenic fungus beauveria bassiana, a well known fungal entomopathogen with high host range and considerable potential in insect pest control. in an isolate selection program of fungal isolates against ecb, ten iso...

entomopathogenic fungi produce secondary metabolites which may bioactively help fungus in its virulence toward insect hosts. beauveria bassiana produces several toxic low molecular compounds in vitro as well as in vivo, the most important of them is beauvericin. the beh isolate of the fungus was selected for beauvericin assay. beauvericin was obtained from surface and submerged cultures of the ...

A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.

In article 1600197, Xueyuan Chen and co-workers report a novel luminescent bioassay technique, namely, dissolution-enhanced luminescence bioassay based on inorganic lanthanide nanoprobes, for ultrasensitive in-vitro detection of tumor markers in human sera or saliva, such as carcinoembryonic antigen, prostate specific antigen and alpha-fetoprotein, with detection sensitivities several orders of...

urine level distribution of antitumor agents, due most likely to the lack of highly sensitive bioassay methods for measuring the concentrations of biologically active ma terials at the low doses generally tolerated by the host. In the present study, cell culture bioassay procedures were used to determine the levels of several clinically use ful or experimental agents in blood and urine after admin

The toxicity data of pesticides were summarized and compared amongst different animal species and types of bioassays. These comparisons showed the expected inter-species and inter-bioassay variability. After quantitative and statistical analysis of these data, it was concluded that, on the average, a 2-year dog bioassay detected toxic responses at similar doses as a 2-year rat study, and that b...