OBJECTIVE(S) Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a m...

Limited permeability through the stratum corneum (SC) is a major obstacle for numerous skin care products. One promising approach to use lipid nanoparticles as they not only facilitate penetration across but also avoid drawbacks of conventional formulations. This review focuses on solid (SLNs), nanostructured nanocarriers (NLCs), and nanoemulsions (NEs) developed topical transdermal delivery ac...

introduction pharmacologic treatment of radicular pain with oral medications is limited by adverse effects and concern for dependence. while topical formulations have been explored in pain research, there is no published literature evaluating the efficacy in radicular pain. we present the first three cases of radicular pain successfully treated with a topical formulation of diclofenac, ibuprofe...

keloids are aesthetically disfiguring and severely disabling. the optimal treatment remains undefined. this clinical study, evaluate the efficacy and side effects of combined topical silicone and 5-fluorouracil on the prevention of keloids. in this double blind randomized clinical trial, fifty patients with keloids were randomly allocated in two groups. the control group were treated by periles...

conclusions although the results of this study showed superiority of application of emla cream as a topical anesthetic for pain relief of blood sampling, both lidocaine 5% and benzocaine 5% offer considerable efficacy in pain relief of venipuncture. results at the end of study, the emla products (a and b) caused a significant decrease in pain (p < 0.05) in comparison with the products c (lidoca...

in order to improve local therapeutic techniques for the massively burnt patients and to minimize the pain associated with dressing change, the concept of topical film was utilized to formulate a topical antimicrobial spray. the commonly used topical antimicrobial silver sulfadiazine spray was formulated as a new drug delivery system. the release of therapeutic agents in vitro from medicated sp...

This case report describes a patient who developed allergic contact dermatitis to chlorhexidine skin preparation applied for transversus abdominis plane block, but not different solution the surgical field. The had presented an elective inguinal hernia repair. He known history of anaphylaxis non-steroidal anti-inflammatory medication was otherwise well. surgery completed uneventfully. Three or ...

Both methyl salicylate and menthol are active substance in many topical formulation commonly used for the treatment of Rheumatic disease[13] due to its analgesics and anti inflammatory activities. It is very difficult to determine these substances in the same preparation due to their similar physical and chemical properties, such as volatility and solubility. Another difficulty is a larger disp...

OBJECTIVE To compare the acute toxicity of common injection and sustained-release preparation of norcantharidin for mice so as to identify the attenuation of the sustained-release preparation of norcantharidin. METHODS The poloxamer 407 was used as a sustained-release vehicle for topical administration of norcantharidin, and the acute toxicity of mice treated with common injection and sustain...

Green tea extract and its principal active ingredient, epigallocatechin gallate (EGCG), are gaining attention and increased usage due to their healthful properties. Despite the increasing demand for these products, few studies have examined their safety. The toxicity of purified green tea extracts containing high concentrations of EGCG have been evaluated in a series of studies in order to defi...