Background Acne is very common and can have a substantial impact on wellbeing. Guidelines suggest first-line management with topical treatments, but there little evidence regarding which treatments are most effective. Objectives To identify the effective best tolerated for acne using network meta-analysis. Methods CENTRAL, MEDLINE, Embase World Health Organization Trials Registry were searched ...

Topical medication delivery is the process of directly treating a cutaneous ailment or manifestation general disease by applying pharmaceutical dosage form to skin with goal reducing drug's pharmacological other effects surface skin. A wide range forms, such as semisolids, liquid preparations, sprays, solid powders, gels, creams, and ointments, are used in topical drug systems. gel cross-linked...

A 28-year-old woman presented with an axillary eczema that occurred after using deodorants. Patch testing revealed contact allergy to aluminium chloride. With avoidance of aluminium-containing deodorants, the eczema cleared completely. Aluminium and its salts are widely used but contact allergy to them is uncommon. It is occasionally recognised incidentally as a reaction to aluminium Finn Chamb...

Twenty patients with recurrent oral ulceration participated in a placebo-controlled, double-blind trail of Mysteclin syrup (tetracycline hydrochloride and amphotericin) used as a mouthwash. Though a small, consistent improvement occurred with placebo, there was a significant reduction in mean pair scores and numbers of new ulcers recorded daily during the active-treatment periods, the effect la...

The aim of the following research was to formulate benzyl benzoate in emulgel form and to evaluate the release of the medicament from it. Emulgel containing 25% w/w of benzyl benzoate was prepared by addition of a gelling agent; Carbopol 934 to an emulsion using Span 80 as emulsifying agent. The release of benzyl benzoate was determined by Franz diffusion cell using cellulose acetate membrane f...

To evaluate the presence of free radicals in various drugs used in ophthalmology. Twenty five samples of drugs that are used by intracameral or intravitreal route, eleven samples of drugs used as fortified eye drop, thirty samples of topical commercial preparations that are used as long term, and eight samples of autologous serum were analyzed for total free radical presence using a kit for tot...

Diabetes mellitus is one of the metabolic disorders that impedes normal steps of wound healing process. Recently, statins have been shown to have anticoagulant, immunosuppressive and antiproliferative effects that could conceivably affect wound healing or the risk of wound complications after surgery or injury. The objective of the present study was to develop formulations of Atorvastatin in di...

OBJECTIVE Topical corticosteroids and corticosteroid combinations are the principal treatments in psoriasis. The aim of this study was to investigate published literature dealing with medical adherence to topical corticosteroid or corticosteroid combinations in patients with psoriasis. MATERIALS AND METHODS Systematic electronic searches in English language literature were done until Septembe...

INTRODUCTION Topical benzocaine is a local anesthetic commonly used to relieve pain caused by teething, periodontal irritation, burns, wounds, and insect bites. Oral preparations may contain benzocaine concentrations ranging from 7.5% to 20%. Pediatric exposure to such large concentrations may result in methemoglobinemia and secondarily cause anemia, cyanosis, and hypoxia. METHODS This is a r...

Antimicrobials are widely used in topical formulations as preservatives or as therapeutically active agents. Photosensitization by such compounds has not yet been studied systematically. To identify possible phototoxic properties, antimicrobials (benzyl alcohol, bronopol, chloracetamide, clioquinol, diazolidinyl urea, ethylenediamine dihydrochloride, formaldehyde, glutaraldehyde, imidazolidinyl...