Motivation: A variety of tools are available to predict the topology of transmembrane proteins. To date no independent evaluation of the performance of these tools has been published. A better understanding of the strengths and weaknesses of the different tools would guide both the biologist and the bioinformatician to make better predictions of membrane protein topology. Results: Here we prese...

<span>This paper defined a new type of topology known as Interior topology. This work falls among the types (such general topology, supra generalized and filter) that are motivated by real-world concepts such orbits planets around sun, electron nucleus, so on. form is self-contained. The primary objective this study to respond question “Is capable producing topology?”. Finally, we define ...

in this paper‎, ‎we mainly investigate how the generalized metrizability properties of the remainders affect the metrizability of rectifiable spaces‎, ‎and how the character of the remainders affects the character‎ ‎and the size of a rectifiable space‎. ‎some results in [a. v‎. ‎arhangel'skii and j‎. ‎van mill‎, ‎on topological groups with a first-countable remainder‎, ‎topology proc. 42 (2013...

The last decade has witnessed a resurgence of interest in Cartesian mesh methods for CFD. In contrast to body-fitted structured or unstructured methods, Cartesian grids are inherently non-body-fitted; i.e. the volume mesh structure is independent of the surface discretization and topology. This characteristic promotes extensive automation, dramatically eases the burden of surface preparation, a...

We consider the sample paths of the order statistics of independent and identically distributed random variables with common distribution function F . If F is strictly increasing but possibly having discontinuities, we prove that the sample paths of the order statistics satisfy the large deviation principle in the Skorokhod M1 topology. Sanov’s theorem is deduced in the SkorokhodM ′ 1 topology ...

We prove, with a few minor exceptions, that if P1 and P2 are probability distributions on the countable set S for which the fixed events E and F are independent, then, both for the standard Euclidean metric and for any metric inducing a topology coarser than the Euclidean topology, there exists a third probability distribution P3 on S that preserves this independence and is equidistant from P1 ...

Using over 75 mus of molecular dynamics simulation, we have generated several thousand folding simulations of the 20-residue Trp cage at experimental temperature and solvent viscosity. A total of 116 independent folding simulations reach RMSDcalpha values below 3 A RMSDcalpha, some as close as 1.4 A RMSDcalpha. We estimate a folding time of 5.5+/-3.5 mus, a rate that is in reasonable agreement ...