conclusions central nervous system depressant was an important risk factor for vap among poisoned patients. hypoventilation due to cns depression can lead to vap. the apache ii and length of hospital stay were shown as independent predictors of vap and mortality among these patients. results the mean age of the patients was 33.9 ± 14.3 years. the probable vap incidence and mortality were 22% an...

objective: vitex agnus-castus (vac) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. in this study, the effects of essential oil extracted from vitex agnus-castus (eovac) leaves were investigated in three behavioral models of nociception in adult male wistar rats. materi...

densely functionalized 3-(4-chlorophenyl)-5-(3-hydroxy-4-etoxyphenyl)-4,5-dihydro-1h-pyrazole-1-carboxamide was  synthesized in an expedient manner through specification and transamidation  respectively, of ester-functionalized pyrazoles. this synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kina...