 The major route of exposure is by inhalation.  Acute inhalation exposure to bromine vapour may cause upper respiratory effects, cough, headache, CNS effects and lacrimation.  Acute oral exposure to bromine results in central nervous system effects.  Deep partial skin loss and skin discolouration have been reported following acute dermal exposure to bromine.  Ocular exposure to bromine cau...

It is known that phototoxicity is related to chemical structure. We have previously reported a prediction method of chemical structure-based in silico phototoxicity for in vitro 3T3 NRUPT assay. To improve the concordance of the method, here we added new descriptors related to another mechanism of phototoxicity. We focused on potential energy, which certainly contributes to chemical reactivity ...

The boiling point is 1530 C., and it is miscible with water and some organic solvents. On boiling with water or alkali it hydrolyzes to formic acid and dimethylamine. It is more stable than formamide and can be distilled. For the present work freshly distilled dimethylformamide was used and all aqueous solutions were freshly prepared. Dimethylformamide in the atmosphere may be trapped by passin...

Air purifiers, which release positive and negative ions generated by electric discharge, are widely used in a variety of places. In this study, male and female SD rats [Crl:CD(SD)] were exposed by whole-body inhalation (6 hr/day) to ionized air containing positive and negative ions for at least 10 weeks before mating and throughout the mating, gestation, and lactation periods over two generatio...

Animal models can help determine the etiology of neurodegenerative diseases such as Parkinson’s disease. Here, we conducted transcriptome analysis of the rotenone model of Parkinson’s disease in rats. Exposure of 9-week-old Wistar rats to rotenone at 3 mg/kg/day for 14 days reduced spontaneous motor activity to 49% of that of control rats. Immunohistochemical analysis revealed increased express...