A new series of N-(5-Mercapto-1,3,4-thiadiazol-2-yl)-2-phenylacetamide derivatives (3a-3j) were synthesized via an amidation reaction using EDC and HOBt in acetonitrile solvent at room temperature condition. Chemical structures were characterized by (1)H NMR, IR and MS spectroscopic methods and related melting points were also determined. The anticancer activity was evaluated using MTT procedur...

The North American pork production industry is heavily dependent on relatively few feed ingredients, including the cereal grains (corn, wheat, and barley), oilseed meals (soybean meal) and industry co-products (DDGS). As such, factors that impact the quality of these feed ingredients can pose serious challenges relative to the formulation of pig diets. One such factor that impacts the quality o...

In this HPLC-diode-array detection method for toxicological drug screening, a mixed-mode solid-phase extraction procedure is optimized for isolation of a broad range of drugs from serum and urine. Basic, neutral, and weakly acidic drugs are uniformly recovered. The extract from the solid-phase cartridge is readily injected to a reversed-phase HPLC column for separation by gradient elution. Unkn...

The emergence of marine toxins in water and seafood may have a considerable impact on public health. Although the tendency in Europe is to consolidate, when possible, official reference methods based on instrumental analysis, the development of alternative or complementary methods providing functional or toxicological information may provide advantages in terms of risk identification, but also ...

background: to determine the role of drugs in fatal overdose, analyses were done on samples obtained from autopsy examination and death and crime scene investigations. the aim of this study was to evaluate the usefulness of toxicology analyses of postmortem biological and non-biological samples belonging to a subject in determining the forensic cause of death. methods: toxicological analysis we...