1H NMR measurements have shown that eight out of twelve methylene hydrogen atoms of 5-hydroxycyclooctanone (1HK) are exchanged for deuterium atoms under acidic and basic conditions. For the reaction in 7.9 M DCl/D2O, an activation energy Ea = 19.2 +/- 0.4 kcal mol(-1) is found. In order to explain these findings, a degenerate transannular 1,5-hydride shift is essential, and this reaction has be...

Percutaneous pulmonary valve implantation (PPVI) is now an accepted alternative option to conventional surgery for patients with dysfunctional conduits between the right ventricle and pulmonary artery. PPVI will reduce the total number of repeat operations in such patients. However, surgery remains the primary option in postoperative tetralogy of Fallot patients with severe pulmonary regurgitat...

transannular patch was placed and stent flow was interrupted with a clip. A 1500-g neonate diagnosed with pulmonary atresia with ventricular septal defect, right aortic arch, ductus left and left superior vena cava, was administered prostaglandin to 2 months and underwent a right MBT shunt. Prostaglandin perfusion was restarted at 24 h as saturation was <65%. Echocardiography detected no flow i...

An 8-year-old (35 kg) boy presented with progressive right ventricular outflow tract enlargement (28 mm) and progressive tricuspid regurgitation after transannular repair of tetralogy of Fallot and was scheduled for pulmonary valve replacement. To spare reoperation on full sternotomy, a transverse mini-thoracotomy through the third intercostal space was used to implant an injectable 29-mm stent...

A4-year-old girl with tetralogy of Fallot had complete repair by open-heart surgery with patch closure of the ventricular septal defect, resection of the pulmonary valve, and placement of a transannular pericardial patch to enlarge the right ventricular outflow tract. On the day of discharge, a 2D echocardiogram revealed a small anterior pericardial effusion and a large pleural effusion, seen h...