Introduction: Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism&n...

Our data describe autophagic flux in primary rat hepatic stellate cells (rHSCs) treated with pro-fibrotic growth factor, transforming growth factor beta (TGF-β). An autophagy flux experiment determines the rate of synthesis and degradation of the autophagosome marker, LC3-II in the presence and absence of the lysosomal inhibitor bafilomcyin, which blocks LC3-II degradation in lysosomes. The eff...

Transforming growth factor beta (TGF-beta) regulates a variety of physiologic processes, including growth inhibition, differentiation, and induction of apoptosis. Some TGF-beta-initiated signals are conveyed through Smad3; TGF-beta binding to its receptors induces phosphorylation of Smad3, which then migrates to the nucleus where it functions as a transcription factor. We describe here the asso...

BACKGROUND: The interaction between the pro- and anti-inflammatory cytokines is known to play key roles in immune response infectious diseases. pathogenesis of malaria parasitemia, including its progression symptomatic manifestation, also seems be strongly related this interplay. AIM: study evaluated plasma levels interferon-gamma (IFN-γ) interleukin-6 (IL)-6, which are inflammatory cytokines, ...

Type beta transforming growth factor-growth inhibitor (TGF beta/GI) causes normal human prokeratinocytes to arrest growth predominantly in the G1 phase of the cell cycle within 48 h after log phase cultures are exposed to the factor in serum-free medium. The growth arrest induced by TGF beta/GI is reversible because the cells from treated cultures can be replated into fresh medium and grown int...

1 Mini-Review: Transforming Growth factor−β and Myostatin Signaling in Skeletal Muscle Helen D. Kollias and John C. McDermott 1 Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland, USA 2 Department of Biology, York University, Toronto, Ontario, Canada The superfamily of transforming growth factor β (TGF-β) cytokines has been shown to have profound effects on cellular proliferat...