The practice of transfusion medicine saves lives, but approximately 2-4% of transfused patients develop alloantibodies against red blood cell antigens, becoming alloimmunized. The alloimmunization index is 10 times higher in transfusion-dependent patients such as those with sickle cell anemia or thalassemia. The determination of red blood cell phenotype by hemagglutination in alloimmunized pati...

BACKGROUND The accentuated nitric oxide (NO) release that is induced by the systemic inflammatory response associated with infective endocarditis (IE) and cardiopulmonary bypass (CPB) may result in catecholamine refractory hypotension (vasoplegia) and increased transfusion requirement due to platelet inhibition. Methylene blue (MB) is an inhibitory drug of inducible NO. We aimed to evaluate the...

OBJECTIVE To determine whether recombinant factor VIIa (rFVIIa) is associated with increased survival and/or thromboembolic complications. INTRODUCTION Uncontrollable hemorrhage is the main cause of early mortality in trauma. rFVIIa has been suggested for the management of refractory hemorrhage. However, there is conflicting evidence about the survival benefit of rFVIIa in trauma. Furthermore...

Background This retrospective study was performed to determine whether postoperative intravenous ferric carboxymaltose reduces transfusion amounts without influencing clinical outcomes in patients that have undergone hip surgery. Methods Between May 2014 and April 2016, the authors adopted a new perioperative blood management protocol involving the administration of intravenous ferric carboxy...

OBJECTIVES To determine the frequency of alloimmunization against human platelet antigens (HPAs) and human leucocyte antigen class 1 (HLA1) in multiparous women and multi-transfused patients.   METHODS This prospective study was conducted between January and August 2013, on 50 multiparous women with no history of previous blood transfusion recruited from the Obstetrics and Gynecology Clinic, ...

Orthopedic trauma patients are routinely transfused for anemia even when asymptomatic at rest, despite there being relatively little scientific evidence as to what level of anemia can be safely tolerated. Some surgeons prefer a more liberal approach, transfusing to keep hemoglobin (Hgb) levels at 7.0 g/dL or higher; others prefer a more conservative approach, allowing Hgb levels to drop below 7...

Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...

Blood donation is someone who voluntarily gives blood; then, the feasibility processed and transfused to patients in need. donors come from voluntary blood or substitute donors/families certain communities. The COVID-19 pandemic spread of a coronavirus epidemic that has various continents countries. This research quantitative descriptive study with time approach used as retrospective. number do...

For more than 40 years now, platelet transfusion has provided life-saving supportive therapy to hematological patients with impaired hematopoiesis, bone marrow aplasia induced by chemotherapy, surgical patients and patients with a variety of disorders of platelet count and function. More than 2.9 million platelet components are transfused each year in Europe and 57000 in Croatia. Patients with ...