objective: the results of the previous studies on the correlation between plasma levels of homocysteine (hcy) and ischemic stroke have been controversial. the aim of the present study is to investigate this correlation meticulously observing risk factors for the ischemic stroke as well as factors affecting the plasma levels of hcy. method: a case-control study was conducted between 2005-2006 wi...

increased levels of proinflammatory cytokines have been recorded after the onset  of transient  or  permanent  brain  ischemia and  are  usually associated with  exacerbation  of ischemic injury. embolic stroke model is more relevant to the pathophysiological situation in such  patients, because the  majority of  ischemic injuries in humans  are induced  by old thrombi that originate from the h...

We present the Long Term ST Database, a collection of eighty 24-hour two and three lead ECG records from ambulatory subjects with transient ST segment abnormalities. The database provides a comprehensive standard research resource for quantitatively assessing the performance of automated detectors of transient ischemia, and for supporting basic research into the mechanisms and dynamics of trans...

BACKGROUND AND PURPOSE Arterial hypoxia mediates cerebral arteriolar dilation primarily via mechanisms involving activation of ATP-sensitive K+ channels (K[ATP]), which we have shown to be sensitive to ischemic stress. In this study, we determined whether ischemia/reperfusion alters cerebral arteriolar responses to arterial hypoxia in anesthetized piglets. Since adenosine plays an important rol...

Atrial fibrillation may remain undiagnosed until an ischemic stroke occurs. In this retrospective cohort study we assessed the prevalence of ischemic stroke or transient ischemic attack as the first manifestation of atrial fibrillation in 3,623 patients treated for their first ever stroke or transient ischemic attack during 2003-2012. Two groups were formed: patients with a history of atrial fi...

BACKGROUND AND PURPOSE Cervical artery dissection (CAD) accounts for 10-20% of ischemic strokes in young adults. Although trauma and preexisting disorders of the arterial wall are the main predisposing factors, most CADs are considered 'spontaneous'. We hypothesized that CAD could originate in systemic vascular disease bound to the intima-media interface without clinical signs. If this hypothes...

Reports on the long-term prognosis of patients with transient ischemic attacks and normal angiograms have revealed variable results, some suggesting a good prognosis while others report an outcome no different from that of patients with transient ischemic attacks and atherosclerotic vascular narrowing. Normal cerebral angiograms do not exclude disease in the heart or hematologic disorders. The ...