The formation of the translation initiation complex represents the rate-limiting step in protein synthesis. Translation initiation in the crenarchaeon Sulfolobus solfataricus depends on several translation IFs (initiation factors), some of which have eukaryal but no bacterial counterparts. In the present paper, we review the current knowledge of the structure, function and evolution of the IFs ...

It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating ...

We describe the development and conceptual evolution of handheld spoken phrase translation systems, beginning with an initial unidirectional system for translation of English phrases, and later extending to a limited bidirectional phrase translation system between English and Pashto, a major language of Afghanistan. We review the challenges posed by such projects, such as the constraints impose...

Neural machine translation has meant a revolution of the field. Nevertheless, postediting the outputs of the system is mandatory for tasks requiring high translation quality. Post-editing offers a unique opportunity for improving neural machine translation systems, using online learning techniques and treating the post-edited translations as new, fresh training data. We review classical learnin...

In the past decade, in vitro transcription/translation technologies have emerged as discovery tools for screening large protein expression libraries, for the selection of engineered polypeptide libraries, and as alternatives to conventional heterologous expression for protein production. Therapeutic proteins and peptides discovered using ribosome-based display methods that link genetic informat...

Introduction: The Dysphagia Handicap Index (DHI) is one of the instruments used for measuring a dysphagic patient’s self-assessment. In some ways, it reflects the patient’s quality of life. Although it has been recognized and widely applied in English speaking populations, it has not been used in its present forms in Persian speaking countries. The purpose of this study was to adapt a Persian v...

introduction: the dysphagia handicap index (dhi) is one of the instruments used for measuring a dysphagic patient’s self-assessment. in some ways, it reflects the patient’s quality of life. although it has been recognized and widely applied in english speaking populations, it has not been used in its present forms in persian speaking countries. the purpose of this study was to adapt a persian v...

The notion of Translation Quality Assessment has been the object of many studies. TQA as the compre- hensive treatment of translation evaluation, focuses on the relationship between the source text and target text and also emphasizes that translation is a linguistic operation. To accomplish this research, House‟s model of TQA was chosen as the framework for the investigation ...

Translation of the coding potential of a messenger RNA into a protein molecule is a fundamental process in all living cells and consumes a large fraction of metabolites and energy resources in growing cells. Moreover, translation has emerged as an important control point in the regulation of gene expression. At the level of gene regulation, translational control is utilized to support the speci...