Human hepatic membrane-embedded transporter proteins are involved in trafficking endogenous and exogenous substrates. Even though impact of transporters on pharmacokinetics is recognized, little is known on maturation of transporter protein expression levels, especially during early life. We aimed to study the protein expression of 10 transporters in liver tissue from fetuses, infants, and adul...

Whole-genome transporter analyses have been conducted on 141 organisms whose complete genome sequences are available. For each organism, the complete set of membrane transport systems was identified with predicted functions, and classified into protein families based on the transporter classification system. Organisms with larger genome sizes generally possessed a relatively greater number of t...

Electric vehicles are considered as technology which can significantly reduce the problems related to road transport such as increasing GHG emissions, air pollutions and energy import dependency. The core objective of this paper is to analyze the current energetic, ecological and economic characteristics of different types of electric vehicles. The major conclusions of this analysis are: The hi...

Purpose: discuss actual application value of the diffusion theory in massive electric vehicle charging load; Method: introduce single vehicle charging process, extend it to charging process of two and multiple electric vehicles, abstract physical process of parallel charging of electric vehicles, introduce energy block concept and diffusion theory, and establish diffusion charging model of elec...

Dopamine transporter deficiency syndrome due to SLC6A3 mutations is the first inherited dopamine 'transportopathy' to be described, with a classical presentation of early infantile-onset progressive parkinsonism dystonia. In this study we have identified a new cohort of patients with dopamine transporter deficiency syndrome, including, most significantly, atypical presentation later in childhoo...

Creatine, a compound that is critical for energy metabolism of nervous cells, crosses the blood-brain barrier (BBB) and the neuronal plasma membrane with difficulty, and only using its specific transporter. In the hereditary condition where the creatine transporter is defective (creatine transporter deficiency) there is no creatine in the brain, and administration of creatine is useless lacking...

In this paper, we analyze the emissions caused by private gasoline vehicles based on a random sample of 950 vehicles. Different types of pollutants; carbon monoxide (CO), carbon dioxide (CO2) and hydrocarbon (HC) were analyzed based on the Jordanian emission standards with special reference to three different vehicles' manufacturing countries; namely: Korea, Japan and Germany. The analysis resu...

This study performed a preliminary analysis of the cumulative on-road safety record of selfdriving vehicles for three of the ten companies that are currently approved for such vehicle testing in California (Google, Delphi, and Audi). The analysis compared the safety record of these vehicles with the safety record of all conventional vehicles in the U.S. for 2013 (adjusted for underreporting of ...

Patients undergoing continuous ambulatory peritoneal dialysis are classified according to their peritoneal permeability as low transporter (low solute permeability) or High transporter (high solute permeability). Factors that determine the differences in permeability between them have not been fully disclosed. We investigated morphological features of cultured human peritoneal mesothelial cells...

Complementary DNA encoding a facilitative glucose transporter was isolated from a human hepatoma cell line (HepG2) cDNA library and subcloned into a metal-inducible mammalian expression vector, pLEN (California Biotechnology) containing human metallothionein gene II promoter sequences. Chinese hamster ovary (CHO) cells transfected with this transporter expression vector, pLENGT, exhibited a 2-1...