We investigated biodegradability and new bone formation after implantation of tetrapod-shaped granular artificial bone (Tetrabone®) or β-tricalcium phosphate granules (β-TCP) in experimental critical-size defects in dogs, which were created through medial and lateral femoral condyles. The defect was packed with Tetrabone® (Tetrabone group) or β-TCP (β-TCP group) or received no implant (control ...

Large segmental bone loss and resection due to trauma and/or the presence of tumors cysts often results in a delay healing or non-union. Currently, autograft is most frequently used strategy manage large loss. Nevertheless, harvesting has limitations, namely sourcing material, requirement an invasive procedure, susceptibility infection. These disadvantages can result complications development s...

The effect of -tricalcium phosphate additive on the alumina matrix was investigated. The sintering behaviour of the alumina tricalcium phosphate composites was characterized by using magic angle spinning nuclear magnetic resonance, X-ray diffraction, dilatometry, differential thermal analysis and scanning electron microscopy analysis. The mechanical properties of composites have been investiga...

Background: Guided bone regeneration (GBR) using osteoconductive graft materials has been used for osseous defect healing. The aim of this translational research study was to design and test a critical size calvarial (CSD) model in rats, GBR with beta-tricalcium phosphate (beta-TCP), histology micro computed tomography (micro-CT) assessment.Methods: Female Wistar albino rats (n=10) weighing 300...

Fabrication of mechanically competent bioactive scaffolds is a great challenge in bone tissue engineering. In this paper, β-tricalcium phosphate (β-TCP) scaffolds were successfully fabricated by selective laser sintering combined with furnace sintering. Bioglass 45S5 was introduced in the process as liquid phase in order to improve the mechanical and biological properties. The results showed th...

Zinc-containing tricalcium phosphate (Zn-TCP) was synthesized to investigate the role of zinc in osteoblastogenesis, osteoclastogenesis and in vivo bone induction in an ectopic implantation model. Zinc ions were readily released in the culture medium. Zn-TCP with the highest zinc content enhanced the alkaline phosphatase activity of human bone marrow stromal cells and tartrate-resistant acid ph...

The present study was conducted to investigate a supplemental effect of magnesium hydrogen phosphate (MHP, MgHPO4) as an alternative phosphorus (P) source on growth and feed utilization of juvenile far eastern catfish (Silurus asotus) in comparison with three conventional P additives (monocalcium phosphate (MCP), dicalcium phosphate (DCP) and tricalcium phosphate [TCP]) as positive controls. A ...

Synthetic calcium phosphates, e.g., hydroxyapatite (HAP) and tricalcium phosphate (TCP), are the most commonly used bone-graft materials due to their high chemical similarity natural hydroxyapatite—the inorganic component of bones. Calcium in form a free ion or bound complexes plays key role many biological functions, including bone regeneration. This paper explores possibility increasing Ca2+-...

Treatment of large bone defects using synthetic scaffolds remain a challenge mainly due to insufficient vascularization. This study is to engineer a vascularized bone graft by integrating a vascularized biomimetic cell-sheet-engineered periosteum (CSEP) and a biodegradable macroporous beta-tricalcium phosphate (β-TCP) scaffold. We first cultured human mesenchymal stem cells (hMSCs) to form cell...

PURPOSE This study compares the bone formation ability of tricalcium phosphate (TCP) with and without recombinant human bone morphogenetic protein-2 (rhBMP-2) and assesses TCP as a carrier of rhBMP-2. METHODS Bilateral round defects (diameter: 8.0 mm) were formed in the cranium of eight New Zealand white rabbits. The defects were grafted with TCP only (control group) or with rhBMP-2-coated TC...