In dermatology practice, it is very common to hear about „Bodies’’, which refer to a pthological structure with a particular features. Most of them are large and can be seen by light microscopy, but there are few very tiny bodies which can only be seen by electron microscopy. Examples for the latter are comma-shaped body, and the worm-shaped body, seen in histiocytoses like benign cephalic hist...

F Allegue, C Fachal, M Romo, MI López-Miragaya, and S Pérez Secciones de Dermatología, Anatomía Patológica, Hematología, and Microbiología, Hospital do Meixoeiro-CHUVI, Vigo, Pontevedra, Spain These tumors show a normal analytical profile, although 1 incidental case with elevated carcinoembryonic antigen has been published.7 Pathology studies have shown an epithelial growth in the upper half of...

Individuals in a colony of European harvest mice (Micromys minutus) were diagnosed with a variety of skin tumors including papillomas, trichoepitheliomas, and sebaceous carcinomas. Papillomavirus group-specific antigens and viruslike particles were detected in the papillomas. A 7.6-kilobase supercoiled circular DNA, which was cleaved once by EcoRI, was visualized in papilloma extracts by low-st...

Sebaceous naevus is a rare non-melanocytic congenital skin hamartoma. Even more rare is the transformation of these lesions into malignant skin cancers, most notably basal cell carcinomas (BCCs). We discuss a case in an adult with later malignant transformation into BCC reported by clinical pathologists. There is dispute about the accurate incidence of malignant transformation. More recently, r...

BACKGROUND Trichofolliculomas and trichoepitheliomas are benign skin neoplasms originating from hair follicle cells. They result from defects in the signaling pathways that regulate hair follicle morphogenesis and regeneration. Thus they seem to be an excellent model of these processes. It is known that the E-cadherin/beta-catenin system of adhesion molecules plays a crucial role in the mainten...

Seborrheic keratosis is a common benign epidermal tumor histologically composed of basaloid and squamous cells. It mainly occurs on the face, scalp, and trunk, and presents clinically as a well-circumscribed, brownish to black papule, nodule, or plaque. Trichoblastoma is a relatively rare benign, slow-growing tumor showing differentiation toward the primitive hair follicle. It clinically manife...

299 in nevus sebaceus: a study of 596 cases. J Am Acad Dermatol 2000;42:263-8. 2. Laffay L, Depaepe L, d'Hombres A, et al. Histological features and treatment approach of trichoblastic carcinomas: from a case report to a review of the literature. Tumori 2012;98:46e-49e. 3. Ayhan M, Gorgu M, Aytug Z, et al. Trichoblastic carcinoma of the alar region: a case report. Dermatol Surg 2006;32:976-9. 4...

Brooke-Spiegler Syndrome (BSS) is a rare genodermatosis characterized by the progressive formation of adnexal skin tumors in the scalp and face, mainly trichoepitheliomas, cylindromas, and spiradenomas. It has also been associated with salivary glands neoplasms. It is due to mutations in the tumor suppressor gene cylindromatosis (CYLD gene) localized on chromosome 16q12-q13. Around 93 mutations...

Sox9 is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from eleven different types of canine skin neoplasms (squamous papilloma, squamous cell carcinoma, inf...