Cilostazol, a selective type III phosphodiesterase inhibitor, has antiplatelet and vasodilating effects. In this study, the effects of cilostazol on lipid metabolism and lipoprotein lipase (LPL) activity were studied in rats. Cilostazol was administered orally at doses of 30 or 100 mg/kg twice a day for 1-2 weeks to rats. Cilostazol decreased the serum triglyceride level in normolipidemic rats....

The genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in mouse and human heart tissue. Why the heart would express these "lipoprotein assembly" genes has been unclear. Here we demonstrate that the beating mouse heart actually secretes spherical lipoproteins. Moreover, increased cardiac production of lipoproteins (e.g., in mice that express a human apolipoprot...

Oral administration of CC14 to rats produced (a) decreased cholesterol, phospholipid, and triglyceride plasma concentrations and elevated triglyceride levels in liver, (6) several hours later, a growing increase in plasma FFA, and (c) still later, increased plasma cholesterol, triglyceride, and phospholipid concentrations and continually rising liver triglyceride. The accumulation of hepatic tr...

Endogenous adipocyte apolipoprotein E (apoE) plays an important role in adipocyte lipoprotein metabolism and lipid flux. A potential role for hyperglycemia in regulating adipocyte apoE expression and triglyceride metabolism was examined. Exposure of adipocytes to high glucose or advanced glycosylation end product-BSA significantly suppressed apoE mRNA and protein levels. This suppression was si...

The purpose of this article is to review the basic and clinical science relating plasma triglycerides and cardiovascular disease. Although many aspects of the basic physiology of triglyceride production, its plasma transport, and its tissue uptake have been known for several decades, the relationship of plasma triglyceride levels to vascular disease is uncertain. Are triglyceride-rich lipoprote...

OBJECTIVES The purpose of this study is to further confirm the results documented in previous studies and to test the hypothesis of the presence of any correlation and if found, the regression nature of such correlation between triglyceride and glucose levels in one hand and cholesterol and glucose levels in the other hand. METHODS Samples were collected between March and August 2009 from 438...

TRIGLYCERIDE, phospholipid, and cholesterol absorbed from the intestines are transported in the blood stream in the form of chylomicrons and very low density lipoproteins (VLDL)." There is considerable evidence that triglyceride of chylomicrons and VLDL is hydrolyzed during uptake from blood and that this process is catalyzed by lipoprotein l ipase. * Lipoprotein lipase activity is found in tis...

Background and Objective: Medicinal plants are widely known as sources of potential that used in traditional medicine. The effect Crinum glaucum (C. glaucum) aqueous extract on the lipid profile endotoxin-induced rats was evaluated.
 Methodology: Fifty Wistar (male female) were divided randomly into five groups (n = 5). Group 1 is control group. 2 administered C. (1000 mg/kg body weight). ...

Aim To elucidate the impact of liraglutide on kinetics apolipoprotein (apo)B48- and apoB100-containing triglyceride-rich lipoproteins in subjects with type 2 diabetes (T2D) after a single fat-rich meal. Materials Methods Subjects T2D were included study to investigate postprandial apoB48 apoB100 metabolism before 16 weeks l.8 mg/day (n = 14) or placebo 4). Stable isotope tracer compartmental mo...

OBJECTIVE The association between changes in triglyceride concentrations over time and diabetes is unknown. We assessed whether two triglyceride determinations obtained 5 years apart can predict incident type 2 diabetes. RESEARCH DESIGN AND METHODS Triglyceride levels at baseline (time 1) and 5 years later (time 2), followed by subsequent follow-up of 5.5 years, were measured in 13,953 appare...