To investigate whether increased endogenous lipogenesis contributes to elevated plasma lipid levels in individuals with apolipoprotein (apo) E2-associated hyperlipidemia (E2-HL), plasma pool cholesterol and triglyceride fatty acid syntheses were measured in subjects with E2-HL and in those with normal lipid levels. Subjects were given a priming dose of deuterium oxide (D2O) followed by maintena...

We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercross derived from C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E-deficient (apoE(-/-)) mice. Soat1, encoding sterol o-acyltransferase 1, is a functional candidate gene located underneath the proximal linkage ...

Background and Objectives: Dyslipidemia is a family of lipoprotein metabolism disorders manifested by elevated total cholesterol (TC), low-density (LDL-C), triglycerides (TG), reduced high density (HDL-C) concentrations in the blood.[1] was defined according to criteria National Cholesterol Education Program Adult Treatment Panel III. Hypercholesterolemia declared for participants with either ˃...

Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism. In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption diminished hepatic ...

Fast food is becoming increasing popular as a social phenomenon, and it usually contains high fat contents. Matcha one versatile tea, its application in brings lots of new consumers. Herein, high-fat diet containing matcha was prepared, this study we investigated the effects such on lipid metabolism intestinal flora normal diabetic mice. Results showed that diabetes had significant weight loss,...

BACKGROUND/AIMS The aim of this prospective study was to evaluate the clinical, biochemical and histopathological parameters of nonalcoholic steatohepatitis and the conditions associated with this disease. METHODS Twenty-four patients were included in the study, each having been diagnosed with nonalcoholic steatohepatitis on the basis of liver biopsy and elimination of other possible causes o...

Sirolimus (Rapammune, rapamycin, RAPA) is a potent immunosuppressive drug that reduces renal transplant rejection. Hyperlipidemia is a significant side effect of sirolimus treatment, and frequently leads to cardiovascular disease. This study was undertaken to determine the repeatability, reversibility, and dose dependence of the plasma lipid and apolipoprotein altering effects of sirolimus, and...

Hypercholesterolemia is a significant risk factor for coronary artery disease development. Genes influencing nonmonogenic hypercholesterolemia susceptibility in humans remain to be identified. Animal models are key investigative systems because major confounding variables such as diet, activity, and genetic background can be controlled. We performed a 121-marker, total genome-analysis of an F2[...

Background and Objective: In development and progression of atherosclerosis, hypercholesterolemia plays a vital role. Prosopis cineraria L. Druce family, Fabaceae, Leguminosae reported to have various pharmacological potential. Hence, the aim of the present investigation was to evaluate its anti-hyperlipidemic potential against High Fat Diet (HFD) induced hyperlipidemia in the laboratory rat. M...

Hypercholesterolemia is a significant risk factor for coronary artery disease development. Genes influencing nonmonogenic hypercholesterolemia susceptibility in humans remain to be identified. Animal models are key investigative systems because major confounding variables such as diet, activity, and genetic background can be controlled. We performed a 121-marker, total genome-analysis of an F2[...