The new Lcica RM 2165 automatic, heavy-duty microtome has an advanced step motor that permits an exact specimen feed and reproducible sectioning results. Features include 70 mm vertical stroke length, unique step trim function, and programmable specimen retraction. Technical features include a handwheel rocking sectioning mode; the motorized specimen feed can be linked to change the handwheel t...

TRIM proteins contribute to selective autophagy, a process whereby cells target specific cargo for autophagic degradation. In a previously reported screen, TRIM17 acted as a prominent inhibitor of bulk autophagy, unlike the majority of TRIMs, which had positive roles. Nevertheless, TRIM17 showed biochemical hallmarks of autophagy-inducing TRIMs. To explain this paradox, here, we investigated ho...

TRIM proteins contribute to selective autophagy, a process whereby cells target specific cargo for autophagic degradation. In a previously reported screen, TRIM17 acted as a prominent inhibitor of bulk autophagy, unlike the majority of TRIMs, which had positive roles. Nevertheless, TRIM17 showed biochemical hallmarks of autophagyinducing TRIMs. To explain this paradox, here, we investigated how...

The proposed Mars Science Laboratory (MSL) mission is intended to deliver a large rover to the Martian surface within 10 km of the target site. This paper presents computational fluid dynamics (CFD) predictions of forebody heating rates for two MSL entry configurations with fixed aerodynamic trim tabs. Results are compared to heating on a 70-deg sphere-cone reference geometry. All three heatshi...

Microinjection of acetylcholine chloride (ACh) in the nucleus of the solitary tract (NTS) of awake rats caused a transient and dose-dependent hypotension and bradycardia. Because it is known that cardiovascular reflexes are affected by nitric oxide (NO) produced in the NTS, we investigated whether these ACh-induced responses depend on NO in the NTS. Responses to ACh (500 pmol in 100 nl) were st...

Retrotransposon markers have been demonstrated to be powerful tools for investigating linkage, evolution and genetics diversity in plants. In the present study, we identified and cloned three full-size TRIM (terminal-repeat retrotransposon in miniature) group retrotransposon elements from apple (Malus domestica) cv. ‘Antonovka’, the first from the Rosaceae. To investigate their utility as marke...