Epsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice. Triple KO cells displayed a dramatic cell division defect. Additionally, a robust impairment in clathrin-mediated endocytosis was observed, with an acc...

Self-assembly of silver triflate with L in alcohol solvent produces characteristic triple-meso helices [Ag3(L)3(ROH)](CF3SO3)3 (L = diethylbis(4-pyridyl)silane; R = Me, Et, n-Pr, and n-Bu) with six units in each turn. Their unit cell volumes are sensitive to the size of the coordinated alcohol molecules. An unusual "alcohol molecules at triple-meso helices" system is a characteristic reversible...

In order to enhance DNA triple helix stability synthetic oligonucleotides have been developed that bear amino groups on the sugar or base. One of the most effective of these is bis-amino-U (B), which possesses 5-propargylamino and 2'-aminoethoxy modifications. Inclusion of this modified nucleotide not only greatly enhances triplex stability, but also increases the affinity for related sequences...

The phase diagram of a system consisting of hard spheres with an attractive Yukawa interaction is computed by Monte Carlo simulations. Upon decreasing the range of attraction, we find the following scenarios: (a) a stable fluid-fluid and fluid-solid transition, a triple point with fluid-fluid-solid coexistence, and a metastable isostructural solid-solid transition (b) a fluid-fluid and isostruc...

In a globular cluster, hierarchical triple black hole systems can be produced through binary-binary interaction. It has been proposed recently that the Kozai mechanism could drive the inner binary of the triple system to merge before it is interrupted by interactions with other field stars. We investigate qualitatively and numerically the evolution of the eccentricities in these binaries under ...

During human-cobot interaction, transitions often occur between free mode operation and constraint surface following. This paper considers the following typical scenario: an operator of a three-dimensional (e.g. x-y-z or x-y-θ) cobot commands a “join” from free mode to a one-dimensional constraint path. To ensure that this transition is smooth and responsive, a “blend path” is computed that joi...

We present a scheme to realize a deterministic solid-state source of time-bin entangled photon pairs using cavity-assisted piecewise adiabatic passage in a single quantum dot. The quantum dot is embedded inside a semiconductor microcavity, and the interaction of a coherent superposition of two temporally separated input pulses and the cavity mode leads to a piecewise adiabatic passage, which pr...

This paper establishes a link between Noncommutative Geometry and canonical quantum gravity. A semi-finite spectral triple over a space of connections is presented. The triple involves an algebra of holonomy loops and a Dirac type operator which resembles a global functional derivation operator. The interaction between the Dirac operator and the algebra reproduces the Poisson structure of Gener...

We investigate the mean energy, strength and width of the triple giant dipole resonance using sum rules. We point out that the excitation operator for the triple giant dipole resonance must be modified from the naive choice D 3. With the modified excitation operator, the strength and mean energy calculated in the Tomonaga model agree with the harmonic limit and the width is larger than √ 3 time...