BACKGROUND Interferon gamma (IFN-γ), a cytokine produced by a variety of cells is involved in the immune response against M. tuberculosis. It activates the production of other cytokines and molecules that kill mycobacterium. IFN-γ also has diagnostic role in identification of active and latent tuberculosis. OBJECTIVE To determine the level of IFN-γ in the blood of TB patients. METHODS Ninet...

Drug-resistant tuberculosis (TB) is emerging as an important health problem in Togo. From sputum of previously treated TB patients, multidrug-resistant (MDR) TB was diagnosed in 24% (10/42) patients via GeneXpert MTB/RIF compared to 25% (6/24) patients via conventional drug susceptibility testing (BACTEC MGIT 960 system). The agreement between these two methods to detect MDR-TB is excellent. Ho...

INTRODUCTION Multidrug-resistant tuberculosis (MDR-TB) has emerged as a major clinical public health threat and challenges the national TB control program in Malaysia. Data that elaborates on the risk factors associated with the development of MDR-TB is highly limited in this country. This study was aimed to determine the risk factors associated with the development of MDR-TB patients in penins...

Correspondence to: Chen-Yuan Chiang, International Union Against Tuberculosis and Lung Disease, Paris, France. e-mail: [email protected] Article submitted 20 December 2012. Final version accepted 17 February 2013. TUBERCULOSIS (TB) services aim to prevent the transmission of TB through early diagnosis of infectious TB patients and rendering them non-infectious by effective treatment. Keepin...

In 1998-1999, the Baltimore TB control program detected a cluster of 21 tuberculosis (TB) cases. Patients reported frequent travel to various East Coast cities. An investigation was conducted to determine whether transmission of the same Mycobacterium tuberculosis strain was occurring in these other localities. A collaborative investigation among federal, state, and local TB controllers include...

Tuberculosis (TB) is one of the oldest and commonest infectious diseases also known as “master of Death”. Pulmonary TB (PTB) and TB with pleural effusion remains a diagnostic challenge. Adenosine deaminase (ADA) is an enzyme of purine catabolism which is an inexpensive and easy test in early routine evaluation of patients with pleural effusion. Aim: To assess the diagnostic level of ADA in TB p...

Background: Tuberculosis is a contagion from ancient times comprising around one 3rd of global population on the wedge infection with Mycobacterium tuberculosis complex where under developed and developing countries coping high burden disease. Aim: To observe most prevalent occupation treatment outcome in both Genders MDR TB patients. Methodology: Health Research Institute-National Institute Ce...

Introduction: Tuberculosis (TB) is one of the major causes of morbidity and mortality worldwide. Also MDR-TB and HIV-TB co-infection are major hurdles in achieving aim and objective of national tuberculosis programme. Material and method: this retrospective study included 1364 suspected patients from April 2016 to March 2017 from registered RNTCP patients. The samples were subjected to Xpert MT...

The World Health Organization (WHO) has set a target of treating 3 million people with antiretroviral treatment (ART) by 2005. In sub-Saharan Africa, HIV-positive tuberculosis (TB) patients could significantly contribute to this target. ART (stavudine/lamivudine/nevirapine) was initiated in Thyolo district, Malawi, in April 2003, and all HIV-positive TB patients were considered eligible and off...

amikacin has been shown to irreversibly suppresscochlear activity.the aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.in this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (mdr-tb) were included.all patients received fixed dose of intravenous amikacin(500 mg...