Royal jelly (RJ) is reflecting the flora around apiaries as a result of foraging activity honeybees and therefore, pollen analysis could be used to verify its botanical/geographical origin. Colon cancer treatment by means chemotherapeutics agents reflects substantial problem for organism due high toxicity other viable cells body. To explore chemopreventive approach enhancing colon efficacy, ant...

Polymorphonuclear neutrophil (PMN) apoptosis was examined in three dogs with pyometra by TUNEL assay in a 24-hr incubation period and compared with that in healthy control dogs (n=5). The incidence of apoptotic PMNs in dogs with pyometra was 26.4 +/- 5% and that in healthy dogs was 54.3 +/- 7%. The results indicated that apoptotic PMN rates in dogs with pyometra were significantly lower than th...


 Purpose: To evaluate the role of miR-20a in sevoflurane (SEV)-induced cognitive impairment rats and to elucidate mechanism action.
 Methods: A SEV-induced rat model was developed. The Morris water maze test fear assay were carried out assess impaired learning memory. cellular SEV-impaired developed level measured animal models. TUNEL staining immunoblot performed determine SEV effec...

Abstract There is a relationship between person’s diet and the development prevention of some cancers. Carotenoids are found as various natural pigments in many fruits vegetables. Studies on carotenoids their potential roles carcinogenesis increasing importance day by day. In this study, we aimed to determine cytotoxic genotoxic effects capsanthin, carotenoid compound, human prostate cancer cel...

Purpose: To investigate the regulatory effects of vesicle-associated membrane protein 8 (VAMP8) in atherosclerosis (AS).
 Methods: VAMP8 expression was assessed using quantitative real time-polymerase chain reaction (qRT-PCR) and western blot, while H&E staining used to examine morphology arterial glandular tissues AS mice. Lipid accumulation mice determined with aid Oil Red O staining...

Purpose: To evaluate the effects of trifolirhizin on diabetic nephropathy (DN), and mechanism action. 
 Methods: Male db/db mice (8 weeks, n = 24) age-matched control (n 6) were obtained. The further divided into four groups administered increasing doses (0, 12.5, 25 50 mg/kg). Histological analysis renal tissues performed by H & E staining. Blood urea nitrogen (BUN) creatinine determi...

Background Oleanolic acid (OA) has notable anti-inflammatory and anti-tumor effects, but the role of OA in cerebral ischemia-reperfusion injury (CIRI) not been reported so far. Methods Oxygen glucose deprivation/reoxygenation (OGD/R) model was induced PC12 cells. MTT assay used to detect cell viability cells, while ELISA detected expression TNF-?, IL-1? IL-6. The superoxide dismutase (SOD), mal...

BACKGROUND AND PURPOSE Cerebral endothelial cells that line microvessels play an important role in maintaining blood flow homeostasis within the brain-forming part of the blood-brain barrier. These cells are injured by hypoxia-induced reperfusion, leading to blood-brain barrier breakdown and exacerbation of ischemic injury. We investigated the roles of vascular endothelial growth factor (VEGF) ...

BACKGROUND The aim of the study is to examine the effect of limited and prolonged hyperoxia on neonatal rat lung. This is done by examining the morphologic changes of apoptosis, the expression of ceramide, an important mediator of apoptosis, the expression of inflammatory mediators represented by IL-1beta and the expression of 2 proto-oncogenes that appear to modulate apoptosis (Bax and Bcl-2)....

CONTEXT Asoprisnil, a selective progesterone (P4) receptor (PR) modulator (SPRM) with mixed P4 agonist/antagonist activities, reduces uterine leiomyoma volume in a dose-dependent manner in the presence of follicular phase estrogen concentrations. The evidence from clinical studies suggests that asoprisnil may directly target the uterine leiomyomata. OBJECTIVE AND METHODS The present study eva...