Atherosclerosis is a very complex pathology. Over the past two decades we have come to appreciate that a major component of this pathological process is chronic inflammation. This inflammatory state is not only characterized by infiltration of lipid laden macrophages, the hallmark cell of this disease, into the vascular wall, but also is characterized by the infiltration of a host of other infl...

There seems to be a love-hate relationship between Brouwer's fixed point theorem and the fundamental theorem of algebra; in this note we offer one more tweak at it, and give a version of Rouchés theorem.

Adipose tissue represents a rich source of multipotent stem cells. Mesenchymal cells, isolated from this source, can differentiate to other cell types in vitro and therefore can be used for a number of regenerative therapies. Our view of adipose tissue has recently changed, establishing adipocytes as new members of the immune system, as they produce a number of proinflammatory cytokines (such a...

Obesity and type 2 diabetes (T2D) are associated with chronic low-grade inflammation. Mounting evidence suggests the involvement of an inflammatory switch in adipose tissue, both in mature adipocytes and immune-competent cells from the stromal vascular compartment, in the progression of obesity and insulin resistance. Several inflammatory cytokines secreted by obese adipose tissue, including TN...

We present a new tweakable block cipher family SKINNY, whose goal is to compete with NSA recent design SIMON in terms of hardware/software performances, while proving in addition much stronger security guarantees with regards to differential/linear attacks. In particular, unlike SIMON, we are able to provide strong bounds for all versions, and not only in the single-key model, but also in the r...

This paper focuses on building a tweakable blockcipher from a classical blockcipher whose input and output wires all have a size of n bits. The main goal is to achieve full 2 security. Such a tweakable blockcipher was proposed by Mennink at FSE’15, and it is also the only tweakable blockcipher so far that claimed full 2 security to our best knowledge. However, we find a key-recovery attack on M...

Acute myocardial infarction and inherited cardiomyopathies, due to extensive loss of cardiomyocytes, may progress towards heart failure despite revascularization procedures and pharmacological treatments. Initial studies supported the concept that bone marrow cells may hold the promise of rebuilding the injured heart from its component elements, offering a valid alternative to the ultimate reso...

We consider the design of a tweakable block cipher from whose inputs and outputs are size n bits. The main goal is to achieve 2n security with large tweak (i.e., more than bits). Previously, Mennink at FSE’15 Wang et al. Asiacrypt’16 proposed constructions that can security. Yet, these have up n-bit only. As evident recent research, generally helpful as building for modes operation, typical app...

In advanced renal cell carcinoma (RCC), surgery combined with systemic chemotherapy and immunotherapy have had limited effectiveness. Therapeutic modalities targeting VEGF, PDGF, and c-kit using tyrosine kinase inhibitors and m-TOR using specific biologic factors are in development. Therapeutic approaches targeting TNF-alpha have shown limited efficacy, while anti-TRAIL (TNFSF10) antibodies hav...

Adipose tissue releases bioactive mediators called adipokines. This review focuses on the effects of omentin, vaspin, cardiotrophin-1, Tumor necrosis factor-like Weak Inducer of Apoptosis (TWEAK) and nephroblastoma overexpressed (NOV/CCN3) on obesity and diabetes. Omentin is produced by the stromal-vascular fraction of visceral adipose tissue. Obesity reduces omentin serum concentrations and ad...